The Influence of Oxytocin on Pair-bonding and Emotion Regulation

NCT ID: NCT02501837

Last Updated: 2015-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2015-06-30

Brief Summary

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The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social behavior and it has been recently shown that OXT also contributes to pair-bonding in men. However, it is still elusive whether OXT has similar effects in women. In the present study, the investigators examine the effect of intranasal OXT on behavioral ratings of and neural responses to the male partner in female participants. In a second experiment, the modulatory effect of OXT on emotion regulation is investigated.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Oxytocin

24 IU Oxytocin (Syntocinon spray), intranasal application 30 min prior to the experiment

Group Type EXPERIMENTAL

Syntocinon-Spray

Intervention Type DRUG

Intranasal administration of 24 IU Oxytocin

Placebo

Intranasal application, containing all ingredients except for the peptide, 3 puffs per nostril

Group Type PLACEBO_COMPARATOR

Syntocinon-Spray

Intervention Type DRUG

Intranasal administration of 24 IU Oxytocin

Interventions

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Syntocinon-Spray

Intranasal administration of 24 IU Oxytocin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy female volunteers
* In a heterosexual relationship

Exclusion Criteria

* Current or past psychiatric disease
* Current or past physical illness
* Psychoactive medication
* Pregnant or lactating
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Bonn

OTHER

Sponsor Role lead

Responsible Party

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Rene Hurlemann

Antragsteller und verantwortlicher Leiter

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Psychiatry, University of Bonn

Bonn, , Germany

Site Status

Countries

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Germany

Related Links

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Other Identifiers

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OXT_BOND

Identifier Type: -

Identifier Source: org_study_id

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