Exercise Intensity and Appetite in Adolescents

NCT ID: NCT02484612

Last Updated: 2016-05-11

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-09-30
• Study Completion Date: 2017-12-31

Brief Summary

Acute exercise has been shown to affect subsequent energy intake in obese adolescents. Indeed, it has been shown several times that an intensive bout of exercise (above 70% of the individual maximal capacities) can reduce energy intake at the following meal in obese adolescents, with no modification of his appetite feelings.

Although this results has been replicated several times, it remains unknown if those nutritional adaptations are due to post-exercise modifications of some gastro-peptides implicated in appetite control, as detailed in adults.

The aim of this work is to question whether or not post-exercise energy intake is explained by appetite-regulating hormones that are affected by the exercise bout in both lean and obese youth.

Detailed Description

After an first medical visit to ensure that the adolescents have the ability to complete the whole study, the participants will have to complete several clinical examinations:

• anthropometric measurements
• Body composition assessed by dual energy x-ray absorptiometry
• Maximal aerobic test

They will then randomly complete the following conditions:

• CON: a control day without exercise;
• HIE: an exercise day with an exercise set at 75% of the capacities
• LIE: an exercise day with an exercise set at 40% of the capacities

The exercises or the rest condition will be done by the end of the morning and a buffet meal will be proposed during which the participants will be asked to eat as much as wanted.

Blood samples will be drawn before, after, 15 after and 30 minutes after the exercise to assess the main appetite regulating hormones involved in appetite regulation (PYY, Cholecystokinin ...) appetite feelings will be assessed throughout the day at regular interval using visual analogue scales.

Conditions

Pediatric Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Lean adolescents

15 lean adolescents (BMI Under the national cut-offs for obesity), 12-15 years old, males, will be recruited

Group Type: EXPERIMENTAL

acute exercise

Intervention Type: BEHAVIORAL

Obese adolescents

15 obese adolescents (BMI above the national cut-offs for obesity), 12-15 years old, males, will be recruited

Group Type: EXPERIMENTAL

acute exercise

Intervention Type: BEHAVIORAL

Interventions

acute exercise

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• 12 to 15 years old adolescents
• Obese according to international values for BMI
• Being registered to the national social security insurance
• no eating disorders
• no medications
• metabolic disorders

Exclusion Criteria

• metabolic disorders
• food disorders
• physical disability

• Minimum Eligible Age: 12 Years
• Maximum Eligible Age: 15 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Université Blaise Pascal, Clermont-Ferrand

OTHER

Sponsor Role: lead

Responsible Party

THIVEL David

PhD, As/Pr, Research scientist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

AME2P Laboratory

Identifier Type: -

Identifier Source: org_study_id