Preventive Strategies in Colorectal Carcinogenesis Production and Meat Processing
NCT ID: NCT02473302
Last Updated: 2015-06-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2014-04-30
2014-07-31
Brief Summary
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The main risk factors associated with colorectal cancer depend of lifestyle, and processed meat and red meat could be involved in carcinogenesis by cytotoxic and genotoxic compound linked to lipid peroxidation and nitrosation.
The aim of this study is to study the impact of the daily consumption of beef, processed or not, on lipid peroxidation induced heme iron ; and to study the impact of the daily consumption of ham, processed or not, on the nitrosilation induced heme iron.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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ham
160g per day during 4 days
ham
160g per day during 4 days
ham + pomegranate extract
160g per day during 4 days
ham + pomegranate extract
160g per day during 4 days
ham + tocopherol
160g per day during 4 days
ham + tocopherol
160g per day during 4 days
rare sirloin steak
110g per day during 4 days
rare sirloin steak
110g per day during 4 days
marinated rare sirloin steak
110g per day during 4 days
marinated rare sirloin steak
110g per day during 4 days
marinated cooked sirloin steak
110g per day during 4 days
marinated cooked sirloin steak
110g per day during 4 days
Interventions
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ham
160g per day during 4 days
ham + pomegranate extract
160g per day during 4 days
ham + tocopherol
160g per day during 4 days
rare sirloin steak
110g per day during 4 days
marinated rare sirloin steak
110g per day during 4 days
marinated cooked sirloin steak
110g per day during 4 days
Eligibility Criteria
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Inclusion Criteria
* Body mass index 20 \<= BMI \<= 30 kg/m2
* Affiliated to French National Health Insurance
* Subject giving his written informed consent
* Subject considered as normal after clinical examination and medical questionnaire
Exclusion Criteria
* Previous familial of colon, ovarian or breast cancer
* Chronic pathologies : cardiovascular diseases, cancer, chronic inflammation diseases, renal, intestinal impairments
* Dislike ham or red meat
* Heavy consumer of alcohol
* Practising intensive physical exercise (\> 5 hours)
* Being under someone's supervision
* Refusal to be registered on the National Volunteers Data file
* Dietary habits unreliable to controlled food intake
* Being in exclusion on the National Volunteers Data file
40 Years
75 Years
MALE
Yes
Sponsors
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Centre de Recherche en Nutrition Humaine d'Auvergne
OTHER_GOV
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
OTHER
Responsible Party
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Adeline BLOT
Clinical research assistant
Principal Investigators
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Fabrice PIERRE, Phd
Role: STUDY_CHAIR
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Noel CANO, Md, Phd
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Clermont-Ferrand
Locations
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CRNH Auvergne
Clermont-Ferrand, Auvergne, France
Countries
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Other Identifiers
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Securiviande
Identifier Type: -
Identifier Source: org_study_id
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