Non-invasive Measurement of Cerebral Dynamic Autoregulation

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2020-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Doppler Flow Wires in Cerebral Angiography

NCT03145701

Aneurysm Cerebral Aneurysm

COMPLETED

Remote Ischemic PreConditioning (RIPC)

NCT03814850

Unruptured Cerebral Aneurysm

WITHDRAWN NA

Transcranial Doppler Using Wearable Ultrasound Patch

NCT06073145

Medical Device Complication Brain Injuries Brain Diseases +2 more

COMPLETED

Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults

NCT02965547

Ischemic Preconditioning

COMPLETED NA

Neuropsychological Functioning and Cerebral Perfusion Post Carotid Endarterectomy

NCT04759859

Carotid Artery Stenosis

WITHDRAWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Stroke

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Intervention

We will measure dCA with both TCD and DCS during acute changes in mean arterial pressure using thigh cuff deflation techniques in vascular risk factor subjects. Measurements will be compared between TCD and DCS in order to validate DCS as a tool to measure dCA in this population.

Group Type EXPERIMENTAL

Thigh Cuff

Intervention Type DEVICE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Thigh Cuff

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age greater than or equal to 50 years
* Positive history of at least one of the following vascular disk factors: hypertension, diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior myocardial infarct, transient ischemic attack, or history of smoking

Exclusion Criteria

* Vascular risk factor subjects:

1. Pregnant women
2. Prisoners
3. Prior neurosurgical procedure or traumatic brain injury, including hemicraniectomy or other skull defect
4. Prior history of ischemic or hemorrhagic stroke
5. Prior lower extremity amputation
6. Peripheral vascular disease

Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No