A Study of Galeterone Compared to Enzalutamide In Men Expressing Androgen Receptor Splice Variant-7 mRNA (AR-V7) Metastatic CRPC

NCT ID: NCT02438007

Last Updated: 2023-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

953 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2016-11-30

Brief Summary

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The purpose of this study is to compare galeterone to enzalutamide in men expressing androgen receptor spice variant-7 mRNA (AR-V7) in metastatic (M1) castrate resistant prostate cancer (CRPC).

Detailed Description

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Conditions

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Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Galeterone

Group Type EXPERIMENTAL

Galeterone

Intervention Type DRUG

2550 mg galeterone tablets once daily PO

Enzalutamide

Group Type ACTIVE_COMPARATOR

Enzalutamide

Intervention Type DRUG

160 mg enzalutamide capsules once daily PO

Interventions

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Galeterone

2550 mg galeterone tablets once daily PO

Intervention Type DRUG

Enzalutamide

160 mg enzalutamide capsules once daily PO

Intervention Type DRUG

Other Intervention Names

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TOK-001 Xtandi®

Eligibility Criteria

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Inclusion Criteria

* Progressive metastatic (M1) disease on androgen deprivation therapy
* Detectable AR-V7 from circulating tumors (CTCs)
* ECOG performance status 0 or 1

Exclusion Criteria

* Prior treatment with second generation anti-androgens (e.g. abiraterone, enzalutamide)
* Prior treatment with chemotherapy for CRPC
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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LTN PHARMACEUTICALS, INC.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Pinnacle Oncology Hematology

Scottsdale, Arizona, United States

Site Status

University Of Arizona Cancer Center

Tucson, Arizona, United States

Site Status

City of Hope

Duarte, California, United States

Site Status

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States

Site Status

UCLA Jonsson Comprehensive Cancer Center

Los Angeles, California, United States

Site Status

Prostate Oncology Specialists, Inc.

Marina del Rey, California, United States

Site Status

UC Davis Cancer Center

Sacramento, California, United States

Site Status

San Bernardino Urological Associates

San Bernardino, California, United States

Site Status

Urology Speciality Group

Torrance, California, United States

Site Status

University of Colorado Cancer Center Anschultz Cancer Pavilion

Aurora, Colorado, United States

Site Status

The Urology Center of Colorado

Denver, Colorado, United States

Site Status

Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Georgetown University Medical Center

Washington D.C., District of Columbia, United States

Site Status

Sibley Memorial Hospital

Washington D.C., District of Columbia, United States

Site Status

Boca Raton Community Hospital, Inc.

Boca Raton, Florida, United States

Site Status

University of Florida Health Cancer Center

Orlando, Florida, United States

Site Status

Moffitt Cancer Center

Tampa, Florida, United States

Site Status

First Urology

Jeffersonville, Indiana, United States

Site Status

Tulane Medical Center

New Orleans, Louisiana, United States

Site Status

Regional Urology, LLC

Shreveport, Louisiana, United States

Site Status

University of Maryland Greenenbaum Cancer Center

Baltimore, Maryland, United States

Site Status

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, United States

Site Status

Walter Reed National Military Medical Center

Bethesda, Maryland, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Site Status

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

University of Michigan Health System

Ann Arbor, Michigan, United States

Site Status

Karmanos Cancer Center

Detroit, Michigan, United States

Site Status

Urology Cancer Center and GU Research Network

Omaha, Nebraska, United States

Site Status

Coastal Urology Associates

Brick, New Jersey, United States

Site Status

Brooklyn Urology Research Group

Brooklyn, New York, United States

Site Status

Advanced Urology Centers of New York

Plainview, New York, United States

Site Status

Premier Medical Group of the Hudson Valley

Poughkeepsie, New York, United States

Site Status

Associated Medical Professionals of NY

Syracuse, New York, United States

Site Status

University of North Carolina Lineberger Cancer Center

Chapel Hill, North Carolina, United States

Site Status

Carolina Urology Partners, PLLC

Charlotte, North Carolina, United States

Site Status

Carolina Urology Partners

Concord, North Carolina, United States

Site Status

The Urology Group

Cincinnati, Ohio, United States

Site Status

Clinical Research Solutions

Middleburg Heights, Ohio, United States

Site Status

Oregon Urology Institute

Springfield, Oregon, United States

Site Status

Lancaster Urology

Lancaster, Pennsylvania, United States

Site Status

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Site Status

UPMC Cancer Centers

Pittsburgh, Pennsylvania, United States

Site Status

Carolina Urologic Research Center

Myrtle Beach, South Carolina, United States

Site Status

Urology Associates Clinical Research

Nashville, Tennessee, United States

Site Status

Urology Clinics of North Texas

Dallas, Texas, United States

Site Status

Texas Oncology/Baylor University Medical Center

Dallas, Texas, United States

Site Status

Urology San Antonio

San Antonio, Texas, United States

Site Status

Virginia Urology

Richmond, Virginia, United States

Site Status

Urology of Virginia

Virginia Beach, Virginia, United States

Site Status

The University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

Madison, Wisconsin, United States

Site Status

St. George Private Hospital, Oncology Day Care Centre

Kogarah, New South Wales, Australia

Site Status

Ashford Cancer Centre/Adelaide Cancer Centre Research

Kurralta Park, New South Wales, Australia

Site Status

North Coast Cancer Institute

Port Macquarie, New South Wales, Australia

Site Status

Prince of Wales Hospital

Randwick, New South Wales, Australia

Site Status

Macquarie University

Sydney, New South Wales, Australia

Site Status

Peninsula Specialist Centre

Kippa-Ring, Queensland, Australia

Site Status

ICON Cancer Care

Southport, Queensland, Australia

Site Status

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Site Status

Ashford Cancer Centre/Adelaide Cancer Centre Research

Kurralta Park, South Australia, Australia

Site Status

Box Hill Hospital

Box Hill, Victoria, Australia

Site Status

Monash Medical Centre

East Bentleigh, Victoria, Australia

Site Status

Peter MacCallum Cancer Centre

East Melbourne, Victoria, Australia

Site Status

Cabrini Hospital

Malvern, Victoria, Australia

Site Status

Jules Bordet Institute Clinique d'Oncologie Medicale

Brussels, , Belgium

Site Status

Universitair Ziekenhuis Gent

Ghent, , Belgium

Site Status

Jessa Ziekenhuis

Hasselt, , Belgium

Site Status

CHU Sart Tilman

Liège, , Belgium

Site Status

British Columbia Cancer

Kelowna, British Columbia, Canada

Site Status

British Columbia Cancer

Vancouver, British Columbia, Canada

Site Status

London Health Sciences Centre

London, Ontario, Canada

Site Status

Sunnybrook Research Institute

Toronto, Ontario, Canada

Site Status

Princess Margaret Hospital

Toronto, Ontario, Canada

Site Status

Centre Hospitalier De I'Universite de Montreal

Montreal, Quebec, Canada

Site Status

Centre Hospitalier Universitaire de Quebec

Québec, Quebec, Canada

Site Status

Centre Paul Papin

Angers, , France

Site Status

Institut Sainte Catherine

Avignon, , France

Site Status

Institut Bergonié

Bordeaux, , France

Site Status

Centre François Baclesse

Caen, , France

Site Status

Service de Médecine Interne Onco-Hématologie

La Roche-sur-Yon, , France

Site Status

Clinique Victor Hugo Centre Jean Bernard

Le Mans, , France

Site Status

Centre Léon Bérard

Lyon, , France

Site Status

Hôpital Edouard Herriot

Lyon, , France

Site Status

Centre Antoine Lacassagne

Nice, , France

Site Status

Centre René Gauducheau

Saint-Herblain, , France

Site Status

Institut de Cancérologie de l'Ouest

Saint-Herblain, , France

Site Status

Institut de Cancerlogie de la Loire

Saint-Priest-en-Jarez, , France

Site Status

Institut Gustave-Roussy

Villejuif, , France

Site Status

Centro Oncologico c/o Presidio Ospedaliero San Donato - Arezzo

Arezzo, , Italy

Site Status

Unità Operativa di Oncologia Ospedale Civile degli Infe

Faenza (RA), , Italy

Site Status

Romagnolo per lo Studio e la Cura dei Tumori IRST-IRCCS - Oncologia medica

Meldola (FC), , Italy

Site Status

AOU "S. Luigi", SCDU Oncologia Medica

Orbassano (Torino), , Italy

Site Status

Az. Ospedaliera San Camillo-Forlanini

Roma, , Italy

Site Status

University of Turin

Torino, , Italy

Site Status

Santa Chiara Hospital

Trento, , Italy

Site Status

Hospital Clínic i Provincial de Barcelona-Oncology

Barcelona, , Spain

Site Status

Instituto Catalan de Oncologia (Hospital Durans i Reynals)

Barcelona, , Spain

Site Status

Hospital General Universitario de Elche

Elche, , Spain

Site Status

Hospital General Universitario Gregorio Marañón

Madrid, , Spain

Site Status

Spanish National Cancer Research Centre

Madrid, , Spain

Site Status

Fundación Althaia Manresa

Manresa, , Spain

Site Status

Unidad Cnio Ibima de Investigacion en Prostata

Málaga, , Spain

Site Status

Hospital Son Espases - Oncología

Palma de Mallorca, , Spain

Site Status

Hospital Clinico Universitario de Navarra

Pamplona, , Spain

Site Status

Consorci Hospitalari de Parc Taulí

Sabadell, , Spain

Site Status

Hospital Universitario Virgen del Rocio

Seville, , Spain

Site Status

IVO-Oncología Médica

Valencia, , Spain

Site Status

CR-UK Institute for Cancer Studies

Birmingham, England, United Kingdom

Site Status

Sussex Cancer Centre

Brighton, England, United Kingdom

Site Status

University College of London Hospitals

London, England, United Kingdom

Site Status

Guy's and St. Thomas' NHS Foundation Trust

London, England, United Kingdom

Site Status

Southampton General Hospital

Southampton, England, United Kingdom

Site Status

University of Surrey Post Graduate Medical Hospital

Surrey, England, United Kingdom

Site Status

Royal Marsden Hospital

Surrey, England, United Kingdom

Site Status

The Royal Cornwall Hospital

Truro, England, United Kingdom

Site Status

The Beatson West of Scotland Cancer Centre

Glasgow, Scotland, United Kingdom

Site Status

Velindre Hospital

Cardiff, Wales, United Kingdom

Site Status

Countries

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United States Australia Belgium Canada France Italy Spain United Kingdom

References

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Aragon-Ching JB. The promising role of poly(ADP-ribose) polymerase inhibitors in prostate cancer. Asian J Androl. 2016 Jul-Aug;18(4):592-3. doi: 10.4103/1008-682X.172821.

Reference Type DERIVED
PMID: 26908063 (View on PubMed)

Other Identifiers

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ARMOR3-SV

Identifier Type: -

Identifier Source: org_study_id

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