Cabazitaxel Versus the Switch to Alternative AR Targeted Therapy Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Primary Resistant Patients to Abiraterone or Enzalutamide

NCT ID: NCT02379390

Last Updated: 2019-06-21

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-06-17
• Study Completion Date: 2018-05-10

Brief Summary

Primary Objective:

To demonstrate the superiority in term of radiographic Progression-Free Survival (rPFS) of cabazitaxel at at 25 milligram per meter square (mg/m^2) plus prednisone (Arm A) versus either enzalutamide at 160 milligram (mg) once daily or abiraterone acetate at 1000 mg once daily plus prednisone (Arm B) in chemotherapy-naïve participants with metastatic Castration-Resistant Prostate Cancer (mCRPC) who have disease progression while receiving androgen receptor (AR) targeted therapy (abiraterone plus prednisone or enzalutamide) within 12 months of treatment initiation (≤12 months).

Secondary Objective:

• To compare efficacy for:
• Prostate-specific antigen (PSA) response rate and Time to PSA progression (TTPP).
• Progression Free Survival (PFS).
• Overall Survival (OS).
• Tumor response rate in participants with measurable disease (RECIST 1.1)
• Pain response and time to pain progression.
• Symptomatic skeletal events (SSE) rate and time to occurrence of any SSE.
• To analyze messenger ribonucleic acids (mRNAs) including androgen-receptor splice variant 7 messenger RNA (AR-V7) as a biomarker in Circulating Tumor Cells (CTCs).
• To evaluate safety in the 2 treatment arms.

Detailed Description

The duration of the study per participant was approximately 2 years. Each participant was treated until radiographic disease progression, unacceptable toxicity, or participants refusal of further study treatment, and each participant was followed after completion of study treatment until death, study cutoff date, or withdrawal of participant consent.

Conditions

Prostate Cancer Metastatic

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Cabazitaxel

Participants received Cabazitaxel 25 mg/m\^2, intravenously for 1 hour along with prednisone 10 mg orally on Day 1 of every treatment cycle (each cycle was of 3 weeks) until disease progression, unacceptable toxicity, or participant's refusal of further study treatment.

Group Type: EXPERIMENTAL

Cabazitaxel XRP6258

Intervention Type: DRUG

Prednisone

Intervention Type: DRUG

Abiraterone acetate or Enzalutamide

Participants received abiraterone acetate 1000 mg (4 tablets of 250 mg), orally once daily along with prednisone 5 mg, orally twice daily from Day 1 to 21 in each treatment cycle (each cycle was of 3 weeks) or enzalutamide 160 mg, orally, until disease progression, unacceptable toxicity, or participant's refusal of further study treatment.

Group Type: ACTIVE_COMPARATOR

Ezalutamide

Intervention Type: DRUG

Abiraterone acetate

Intervention Type: DRUG

Prednisone

Intervention Type: DRUG

Interventions

Cabazitaxel XRP6258

Intervention Type: DRUG

Ezalutamide

Intervention Type: DRUG

Abiraterone acetate

Intervention Type: DRUG

Prednisone

Intervention Type: DRUG

Other Intervention Names

Jevtana; Xtandi; Zytiga

Eligibility Criteria

Inclusion Criteria

• Diagnosis of histologically or cytologically confirmed prostate adenocarcinoma.
• Metastatic disease.
• Progressive disease (PD) while receiving AR targeted therapy with abiraterone acetate or enzalutamide within 12 months of treatment initiation (≤12 months) by at least one of the following:
• Progression in measurable disease Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.
• Appearance of 2 or more new bone lesions according to Prostate Cancer Working Group 2 (PCWG2).
• Rising PSA defined (PCWG2) as at least two consecutive rises in PSA to be documented over a reference value (measure 1) taken at least one week apart.
• A PSA value of at least 2 nanogram/milliliter (ng/mL) is required at study entry.
• Effective castration (serum testosterone levels ≤0.5 ng/mL).
• Prior AR targeted therapy (abiraterone acetate or enzalutamide) must be stopped at least 2 weeks before study treatment.
• Signed written informed consent.

Exclusion Criteria

• Prior chemotherapy for prostate cancer, except estramustine and except adjuvant/neoadjuvant treatment completed >3 years ago. No further anti-cancer therapy after the previous AR targeted therapy and before inclusion. Prior docetaxel in hormone sensitive setting is allowed if completed >1 year before randomization. Prior immunotherapy is allowed.
• Less than 28 days elapsed from prior treatment with immunotherapy, radiotherapy, or surgery to the time of randomization.
• Eastern Cooperative Oncology Group (ECOG) performance status >1.
• History of brain metastases, uncontrolled spinal cord compression, or carcinomatous meningitis, or new evidence of brain or leptomeningeal disease.
• Prior malignancy. Adequately treated basal cell or squamous cell skin or superficial (pTis, pTa, and pT1) bladder cancer are allowed, as well as any other cancer for which treatment has been completed ≥5 years ago and from which the patient has been disease-free for ≥5 years.
• Participation in another clinical trial and any concurrent treatment with any investigational drug within 30 days prior to randomization.
• Acquired immunodeficiency syndrome (AIDS)-related illnesses or known Human immunodeficiency virus (HIV) disease requiring antiretroviral treatment.
• Any severe acute or chronic medical condition including uncontrolled diabetes mellitus, severe renal impairment, history of cardiovascular disease (uncontrolled hypertension, arterial thrombotic events in the past 6 months, congestive heart failure, severe or unstable angina pectoris, recent myocardial infraction within last 6 months or uncontrolled cardiac arrhythmia), which could impair the ability of the patient to participate to the study or interfere with interpretation of study results, or patient unable to comply with the study procedures.
• Participants with reproductive potential who do not agree to use accepted and effective method of contraception during the study treatment period and up to 6 months after the last administered dose. The definition of "effective method of contraception" will be based on the Investigator's judgment.
• Known allergies, hypersensitivity or intolerance to prednisone or excipients of abiraterone acetate or enzalutamide. History of hypersensitivity to docetaxel or polysorbate 80.
• Known history of mineralocorticoid excess or deficiency (not applicable to participants who have already been treated with abiraterone acetate in first line before inclusion).
• History of seizure, underlying brain injury with loss of consciousness, transient ischemic attack within the past 12 months, cerebral vascular accident, brain arteriovenous malformation or the use of concomitant medications that may lower the seizure threshold (not applicable to participants who have already been treated with enzalutamide in first line before inclusion).
• Unable to swallow a whole tablet or capsule.
• Inadequate organ and bone marrow function as evidenced by:
• Hemoglobin <10.0 g/dL.
• Absolute neutrophil count <1.5 x 10^9/L.
• Platelet count <100 x 10^9/L.
• Aspartate aminotransferase (AST) and/or Alanine aminotransferase (ALT) >1.5 x Upper limit of normal (ULN).
• Total bilirubin >1.0 x ULN.
• Potassium <3.5 mmol/L.
• Serum albumin <3.0 g/dL.
• Child-Pugh Class B and C.
• Contraindications to the use of corticosteroid treatment.
• Symptomatic peripheral neuropathy grade ≥2 NCI CTCAE v4.0.
• Concomitant vaccination with yellow fever vaccine.

The above information was not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Sanofi

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Clinical Sciences & Operations

Role: STUDY_DIRECTOR

Sanofi

Locations

Investigational Site Number 840030

Muscle Shoals, Alabama, United States

Investigational Site Number 840024

Anchorage, Alaska, United States

Investigational Site Number 840028

Anaheim, California, United States

Investigational Site Number 840004

Sacramento, California, United States

Investigational Site Number 840002

Boca Raton, Florida, United States

Investigational Site Number 840027

Lakeland, Florida, United States

Investigational Site Number 840006

Port Saint Lucie, Florida, United States

Investigational Site Number 840015

Ottawa, Illinois, United States

Investigational Site Number 840001

Covington, Louisiana, United States

Investigational Site Number 840017

Metairie, Louisiana, United States

Investigational Site Number 840012

Rockville, Maryland, United States

Investigational Site Number 840026

Omaha, Nebraska, United States

Investigational Site Number 840022

Canton, Ohio, United States

Investigational Site Number 840016

Myrtle Beach, South Carolina, United States

Investigational Site Number 124003

Edmonton, , Canada

Investigational Site Number 124010

Greenfield Park, , Canada

Investigational Site Number 124005

Hamilton, , Canada

Investigational Site Number 124004

London, , Canada

Investigational Site Number 124002

Montreal, , Canada

Investigational Site Number 124006

Montreal, , Canada

Investigational Site Number 124007

Ottawa, , Canada

Investigational Site Number 124009

Québec, , Canada

Investigational Site Number 124008

Saskatoon, , Canada

Investigational Site Number 124001

Vancouver, , Canada

Countries

United States; Canada

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

U1111-1160-6008

Identifier Type: OTHER

Identifier Source: secondary_id

LPS14022

Identifier Type: -

Identifier Source: org_study_id