Dynamic of the Acquisition of Antibiotic Resistance in Integrons in Neonatology Newborns

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

278 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-31

Study Completion Date

2016-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Antibiotic resistance is a major public health issue as multiresistant bacteria (MRB) are increasing. Among the actions to control resistance, one is an interesting lead: to prevent the emergence of resistant bacteria by limiting possibilities for bacteria to acquire resistance. Mechanisms of resistance genes acquisition are deeply studied but there are few data on the dynamic of acquisition over time. Among the genetic components that disseminate resistance genes, resistance integrons (RI) play a major role in the acquisition and dissemination of antibiotic resistance in gram-negative bacteria. The digestive tract of the newborn (NB), which is initially sterile, is colonized by a bacterial microbiota during the first days of life. It thus appears to be an appropriate model to study the dynamic of resistance acquisition. This project intends to follow the NB of neonatology over time in order to study the dynamic of the digestive acquisition of RI and MRB

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

New Dosages of Inflammatory Markers for the Early Diagnosis of Nosocomial Bacterial Infections of the Newborn

NCT00701948

Nosocomial Infection

COMPLETED

CCA of SGB PCR Versus SGB Culture at 35-38 SA in the Optimization of Intrapartum Antibiotic Prophylaxis

NCT05005169

Streptococcus Agalactiae

COMPLETED NA

Early Antibiotic Therapy and Vaccinations in Preterm Infants

NCT05563753

Vaccination Reaction

UNKNOWN

Dynamics of the Microbiome in the Premature Infant

NCT02121938

Infection

COMPLETED

Follow-up of the Nasal Microbiome and Viral Infections in Newborns Hospitalised in Neonatology.

NCT05717283

Microbial Colonization Viral Infection Neonatal Infection

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Bacteriology

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Mother-child pairs that will be included in the study will be the pairs of all the NB, born in the center (in born) and hospitalized in the neonatology units of each center:

with a predictable stay ≥ 3 weeks in the unit

Exclusion Criteria

NB will not be included if:

* They exhibit a birth defect, especially on the digestive tract
* They are secondarily hospitalized after a postnatal transfer (out born).
* The parents express their objection for the child to take part in the study
* The stool sample of the mother has not been received

Maximum Eligible Age

1 Day

Eligible Sex

ALL

Accepts Healthy Volunteers

No