Cannabinoids, Learning, and Memory

NCT ID: NCT02407808

Last Updated: 2025-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE1

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-28

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The overarching goal of this study is to characterize the effects of cannabinoids on working and episodic memory.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cannabis Psychotic Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

THC

Active THC (0.0015mg/kg-0.03mg/kg) administered over 20 minutes.

Group Type ACTIVE_COMPARATOR

THC

Intervention Type DRUG

Active THC (0.0015-0.03 mg/kg) administered over 20 minutes.

Placebo

Intervention Type DRUG

Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.

Placebo

Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.

Group Type PLACEBO_COMPARATOR

THC

Intervention Type DRUG

Active THC (0.0015-0.03 mg/kg) administered over 20 minutes.

Placebo

Intervention Type DRUG

Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

THC

Active THC (0.0015-0.03 mg/kg) administered over 20 minutes.

Intervention Type DRUG

Placebo

Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Men and women aged 18 and 55 years (extremes included) on day of first dosing
* Exposed to cannabis at least once in their lifetime

Exclusion Criteria

* Cannabis naive
* Positive pregnancy screen during screening
* Hearing deficits
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Yale University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Mohini Ranganathan

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Mohini Ranganathan, M.D.

Role: PRINCIPAL_INVESTIGATOR

Assistant Professor

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

VA Connecticut Healthcare System

West Haven, Connecticut, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

No NIH funding

Identifier Type: OTHER

Identifier Source: secondary_id

1501015211

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

CB1R in Synthetic Psychoactive Cannabinoids
NCT03539575 ACTIVE_NOT_RECRUITING NA
The Effects of ∆-9-THC and Naloxone in Humans
NCT01591629 COMPLETED EARLY_PHASE1
Behavioral Pharmacology of THC and Beta-Myrcene
NCT05432284 NOT_YET_RECRUITING PHASE1