CB1R in Synthetic Psychoactive Cannabinoids

NCT ID: NCT03539575

Last Updated: 2025-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2025-12-31

Brief Summary

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The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.

Detailed Description

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Conditions

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Drug Dependence

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Synthetic Psychoactive Cannabinoid Users

Synthetic Psychoactive Cannabinoid dependent subjects who are frequent spice/K2 users will receive the radiotracer \[11-C\]OMAR.

Group Type OTHER

[11-C]OMAR

Intervention Type OTHER

The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Interventions

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[11-C]OMAR

The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Able to provide written consent
* Age 18-55
* Current Synthetic Psychoactive Cannabinoids consumption

Exclusion:

* MRI metal exclusions and claustrophobia
* Education completed is less than 12 years
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

Yale University

OTHER

Sponsor Role lead

Responsible Party

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Deepak C. D'Souza

Professor of Psychiatry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Deepak C D'Souza, M.D.

Role: PRINCIPAL_INVESTIGATOR

Yale University

Mohini Ranganathan, M.D.

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

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Connecticut Mental Health Center

New Haven, Connecticut, United States

Site Status

Countries

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United States

Other Identifiers

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1R21DA041580-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1308012514A

Identifier Type: -

Identifier Source: org_study_id

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