Improvement of Sleep Quality by RePneu® Coils in Advanced Pulmonary Emphysema

NCT ID: NCT02399514

Last Updated: 2019-02-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-05

Study Completion Date

2018-03-09

Brief Summary

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Improvement of sleep quality in emphysema patients is desirable. Yet, there are no data of patients treated with RePneu coils. This monocenter prospective study investigates the effect on sleep quality of RePneu coils for reduction of dynamic hyperinflation in advanced disease stages of pulmonary emphysema.

Patient's sleep will be studied in three Polysomnography measurement nights, one prior to Coil Treatment, one six months after, and one twelve month after.

Primary objective is to investigate differences in sleep quality 6 and 12 months after Coil Treatment.

Further endpoints are changes in daily activity and sleep (actigraphy), 6MWT, lung function parameters, and questionnaires (SGRQ, mMRC dyspnoe scale).

Detailed Description

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Conditions

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COPD Emphysema

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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RePneum coils

Patients who needed lung volume reduction with RePneum coils

Group Type OTHER

Polysomnographic diagnostic

Intervention Type OTHER

Polysomnographic diagnostic performed one prior to Coil Treatment, one six months after and one twelve month after Coil Treatment

Interventions

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Polysomnographic diagnostic

Polysomnographic diagnostic performed one prior to Coil Treatment, one six months after and one twelve month after Coil Treatment

Intervention Type OTHER

Other Intervention Names

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PSG

Eligibility Criteria

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Inclusion Criteria

* Written consent
* RePneu Coil treatment according to clinical criteria

Exclusion Criteria

* Pregnancy or nursing period
* Participation in another clinical trial within the last 4 weeks
* Incapable of giving consent
* Known OSA (AHI\>10)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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PneumRx, Inc.

INDUSTRY

Sponsor Role collaborator

Institut für Pneumologie Hagen Ambrock eV

INDUSTRY

Sponsor Role lead

Responsible Party

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Karl Josef Franke

Senior Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Karl-Josef Franke, MD

Role: PRINCIPAL_INVESTIGATOR

Helios Klinik Ambrock

Locations

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Helios Klinik Ambrock

Hagen, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Franke KJ, Domanski U, Schroder M, Nilius G. Effects of endobronchial coils for endoscopic lung volume reduction on sleep in COPD patients with advanced pulmonary emphysema. Sleep Breath. 2021 Jun;25(2):727-735. doi: 10.1007/s11325-020-02176-0. Epub 2020 Aug 26.

Reference Type DERIVED
PMID: 32845475 (View on PubMed)

Other Identifiers

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JF001 sleep

Identifier Type: -

Identifier Source: org_study_id

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