Precision Sleep Medicine

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1055 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2024-07-31

Brief Summary

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This retrospective observational study aims to characterize the prevalence and clinical features of obstructive sleep apnea (OSA) phenotypes and develop a rater-independent algorithm for automated OSA phenotyping, improving diagnosis and personalized treatment.

Detailed Description

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Obstructive sleep apnea (OSA) is characterized by repeated upper airway blockages during sleep, but it presents with a range of phenotypic variations, each with potentially distinct clinical implications. Current clinical definitions are not always precise, making it difficult to clearly classify patients with overlapping features. This phenotypic overlap poses challenges for understanding the true prevalence of "pure" versus "mixed" OSA phenotypes and their respective clinical implications.

To comprehensively characterize the prevalence and clinical features of distinct OSA phenotypes in a large, diverse patient population, this retrospective study analyzes polysomnography (PSG) data from two publicly available National Sleep Research Resource datasets. The findings are then compared to datasets from the University Hospital Basel and University Children's Hospital Basel to assess generalizability.

Furthermore, the study employs computer-aided analysis of PSG data to develop rater-independent algorithms for objective and automated OSA phenotyping. These advancements aim to improve understanding of OSA heterogeneity, facilitating more precise diagnoses and personalized treatment strategies.

Conditions

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Obstructive Sleep Apnea

Keywords

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Polysomnography (PSG) recordings

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Adults

Adults who underwent polysomnography recordings at the University Hospital Basel in 2023.

No interventions assigned to this group

Children and adolescents

Children and adolescents who underwent polysomnography recordings at the University Children's Hospital Basel between January 2022 to July 2024.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age 19 years and older (data from University Hospital Basel (USB))
* age 18 years or younger (data from University Children's Hospital Basel (UKBB))
* Epworth Sleepiness Scale (ESS) score available (USB only)
* Diagnosis available (e.g. Obstructive sleep apnea (OSA), Central Sleep Apnea (CSA), Cheyne Stokes Breathing (CSR), ...)
* signed written general consent

Exclusion Criteria

* history of treatment of sleep apnea
* tracheostomy
* current home oxygen therapy
* decline to sign the written general consent, or absence of written general consent

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Matthias Herrmann, Dr. med.

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Basel, Switzerland

Locations

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University Children's Hospital Basel

Basel, Canton of Basel-City, Switzerland

Site Status

University Hospital Basel