Urinary Neurotrophin Levels in Healthy Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-31

Study Completion Date

2016-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to analyse urinary neurotrophin levels in healthy children. Urine samples will be collected at 3 different times of day (morning, noon, and evening) at urge sensation from all age groups of children who gained bladder control, i.e. from 3-18 years of age. Urinary levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) normalised to urinary creatinine will be analysed. Age and daytime related variations will be reported for both boys and girls. These results will contribute to understanding the role of neurotrophins in the physiology of lower urinary tract and pathophysiology of idiopathic and secondary hyperactive bladder in children.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Urinary Markers of Detrusor Overactivity in Spina Bifida Patients

NCT02852317

Spina Bifida Multiple Sclerosis Spinal Cord Injury +1 more

COMPLETED

Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes

NCT03373539

Bronchopulmonary Dysplasia Chronic Lung Disease

COMPLETED

Relationship Between Breathing and Attention in Children With Ondine Syndrome

NCT06337149

Ondine Syndrome Congenital Central Hypoventilation Syndrome (CCHS)

RECRUITING

Theory of Mind in Preschool Children, School Children, Youths and Adults Born Preterm or Full-term

NCT02628015

Premature Birth

UNKNOWN

Incontinence and MRI Results in Children with Cerebral Palsy

NCT05060211

Cerebral Palsy Lower Urinary Tract Symptoms

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Overactive Bladder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy children

Healthy children without lower urinary tract diseases, history of urinary tract infection, chronic diseases, anomalies of urinary or genital tract, and remarkable clinical examination.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 3-18 years of age
* a unremarkable clinical examination
* a normal voiding pattern
* a minimum of 3 micturitions per day
* informed oral and written consent from the child and both parents/legal guardian

Exclusion Criteria

* history of urinary tract infection
* diseases of central or peripheral nerve system
* anomalies of lumbosacral region
* chronic diseases
* operative procedures or anomalies of urinary or genital tract
* lower urinary tract symptoms
* constipation
* hypercalcuria
* urolithiasis, depression, eating disorders or cardio-metabolic diseases
* prior use of anticholinergic treatment

Minimum Eligible Age

3 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes