Identification of Genomic Changes in Families Having Multiple Members With Tumors

NCT ID: NCT02386241

Last Updated: 2024-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

4 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-03-31

Study Completion Date

2019-07-31

Brief Summary

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This study will compare genomic alterations between the parents and the patients with high-grade glioma.

Detailed Description

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Genomic changes leading to the formation of brain tumors are slowly being discovered. Despite advances in genomic technology, much analysis is hindered by the lack of control samples that could better delineate genomic alterations leading to disease. The ideal genomic control would be the genetic material of the parents of afflicted individuals. The researchers propose to then compare the genomic material from parents of siblings, both of whom have a diagnosis of a high-grade glioma. Additionally, the researchers will then compare the genomic alterations between the parents and the patients. This analysis will provide an unprecedented insight into genomic level changes that take place between parents and patients that resulted in the formation of a high-grade glioma.

Conditions

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Glioma

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Interventions

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saliva or blood sample collection

Single saliva or blood sample measuring 10mL for genomic analysis.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years or older.
* Family history of brain tumor in first degree relative

Exclusion Criteria

* less than 18 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Translational Genomics Research Institute

OTHER

Sponsor Role collaborator

St. Joseph's Hospital and Medical Center, Phoenix

OTHER

Sponsor Role lead

Responsible Party

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Lori Wood

Research Operations Manager

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Peter Nakaji, MD

Role: PRINCIPAL_INVESTIGATOR

Saint Joseph's Hospital and Medical Center/Barrow Neurological Institute

Locations

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Barrow Neurological Institute at St. Joseph's Hospital Medical Center

Phoenix, Arizona, United States

Site Status

Countries

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United States

Other Identifiers

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14BN108

Identifier Type: -

Identifier Source: org_study_id

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