Hypothalamo-pituitary Adrenal Axis Activity and Neuropsychological Consequences in Type 1 Diabetes in Childhood
NCT ID: NCT02377583
Last Updated: 2015-03-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
90 participants
OBSERVATIONAL
2012-08-31
2016-02-29
Brief Summary
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Detailed Description
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* Purpose: To describe the association between HPA axis activity and anxiety and depression scores in 6-12 year's old diabetes children.
* Abstract: The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.
Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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Diabetic children
* physical examination
* Glucocorticoid sensitivity index
* DNA sample
* Anxiety and depression questionnaires
* depression questionnaire
* MRI
No interventions assigned to this group
Controls
* physical examination
* Glucocorticoid sensitivity index
* DNA sample
* Anxiety and depression questionnaires
* depression questionnaire
* MRI
* Laboratory tests
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* diabetes for 1 year
* 6-12 year's old
* included in ISIS-DIAB protocol.
* Control group:
* brother or sister of a diabetic children
* 6-12 year's old.
Exclusion Criteria
* Acute infectious disease in the previous week of inclusion.
* Other chronic disease than diabetes type1.
* Psychiatric disorders or psychiatric treatment.
6 Years
12 Years
ALL
Yes
Sponsors
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University Hospital, Bordeaux
OTHER
Responsible Party
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Principal Investigators
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Paul PEREZ, Doctor
Role: STUDY_CHAIR
University Hospital, Bordeaux
Locations
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Service d'endocrinologie pédiatrique CHG Bayonne Centre Hospitalier de la Côte Basque
Bayonne, Aquitaine, France
CHU de Bordeaux Hôpital Pellegrin
Bordeaux, Aquitaine, France
Service d'endocrinologie pédiatrique - Hôpital de la mère et de l'enfant - CHU de LIMOGES
Limoges, Limousin, France
Countries
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Central Contacts
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Facility Contacts
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Pascal BARAT, Professor
Role: primary
Other Identifiers
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CHUBX 2011/24
Identifier Type: -
Identifier Source: org_study_id
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