Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
83 participants
INTERVENTIONAL
2016-07-31
2019-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Exercise Program
The exercise intervention consists of a 30 minute exercise session led by an instructor through a DVD or a video available on the internet.
Exercise Program
They will perform low-intensity, low-resistance exercise facilitated by a DVD video in their home. This exercise program lasts for 30 minutes at a time. Patients will be instructed to engage in this exercise program 3-4 times per week but not more often than 4 times per week. Pre-transplant patients will be asked to do the exercises from enrollment to transplant. Post-transplant patients will be asked to do the exercises for 6 months.
Standard of care
Standard of care which consists of encouragement to exercise by the subject's transplant clinician.
No interventions assigned to this group
Interventions
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Exercise Program
They will perform low-intensity, low-resistance exercise facilitated by a DVD video in their home. This exercise program lasts for 30 minutes at a time. Patients will be instructed to engage in this exercise program 3-4 times per week but not more often than 4 times per week. Pre-transplant patients will be asked to do the exercises from enrollment to transplant. Post-transplant patients will be asked to do the exercises for 6 months.
Eligibility Criteria
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Inclusion Criteria
* Listed for liver transplantation or post-liver transplantation
* English speaking
Exclusion Criteria
* Non-English speaking
* Requires an assistive device for ambulation
* Active hepatic encephalopathy at the time of baseline assessment for enrollment in the study
18 Years
ALL
No
Sponsors
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Johns Hopkins University
OTHER
Duke University
OTHER
University of California, San Francisco
OTHER
Responsible Party
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Principal Investigators
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Jennifer C Lai, MD, MBA
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Locations
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University of California, San Francisco
San Francisco, California, United States
Johns Hopkins University
Baltimore, Maryland, United States
Duke University
Durham, North Carolina, United States
Countries
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References
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Murray KF, Carithers RL Jr; AASLD. AASLD practice guidelines: Evaluation of the patient for liver transplantation. Hepatology. 2005 Jun;41(6):1407-32. doi: 10.1002/hep.20704. No abstract available.
Lai JC, Feng S, Terrault NA, Lizaola B, Hayssen H, Covinsky K. Frailty predicts waitlist mortality in liver transplant candidates. Am J Transplant. 2014 Aug;14(8):1870-9. doi: 10.1111/ajt.12762. Epub 2014 Jun 16.
Dasarathy S. Consilience in sarcopenia of cirrhosis. J Cachexia Sarcopenia Muscle. 2012 Dec;3(4):225-37. doi: 10.1007/s13539-012-0069-3. Epub 2012 May 31.
Jones JC, Coombes JS, Macdonald GA. Exercise capacity and muscle strength in patients with cirrhosis. Liver Transpl. 2012 Feb;18(2):146-51. doi: 10.1002/lt.22472.
Related Links
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United Network for Organ Sharing
Other Identifiers
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14-14783
Identifier Type: -
Identifier Source: org_study_id
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