DISCOVERing Treatment Reality of Type 2 Diabetes in Real World Settings
NCT ID: NCT02322762
Last Updated: 2022-06-09
Study Results
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Basic Information
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COMPLETED
15992 participants
OBSERVATIONAL
2014-12-30
2019-08-21
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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One single cohort.
One single cohort of patients with type 2 diabetes mellitus initiating their second line anti-diabetic therapy after first line anti-diabetic therapy.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Female or male aged 18 years and over
3. Diagnosed with type 2 diabetes mellitus
4. Initiating a second line anti-diabetic therapy, either as add-on, or switching from one monotherapy to another.
Exclusion Criteria
2. Patient is pregnant
3. Patients initiating a dual therapy after having previously received two different lines of monotherapy before (e.g.: Metformin → SU (Sulphonylureas) → SU+Add-on)
4. Current treatment with chemotherapy, oral or iv steroids
5. Patient is on dialysis or has had a renal transplant
6. The patient is taking insulin as first line treatment
7. The patient is taking dual therapy or a fixed dose combination treatment as first line treatment.
8. The patient is taking herbal remedies / natural medicines as first line treatment
9. Participation in an interventional trial
10. Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient for 3 years (e.g. lifethreatening co-morbidities, tourist, non-native speaker or does not understand the local language where interpreter services are not reliably available, psychiatric disturbances, dementia, alcohol or drug abuse).
11. Not willing to sign the informed consent.
18 Years
ALL
No
Sponsors
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AstraZeneca
INDUSTRY
Responsible Party
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Principal Investigators
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Jesus Medina, PhD
Role: STUDY_DIRECTOR
AstraZeneca
Linong Ji, MD
Role: PRINCIPAL_INVESTIGATOR
Peking University People's Hospital, China
Bong Soo Cha, Dr.
Role: PRINCIPAL_INVESTIGATOR
Severance Hospital, Yonsei University Health System
Locations
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Research Site
Algiers, , Algeria
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Batna City, , Algeria
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Blida, , Algeria
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Constantine, , Algeria
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Oran, , Algeria
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Sétif, , Algeria
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Buenos Aires, , Argentina
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Chacabuco, , Argentina
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Ciudad Autonoma Buenos Aires, , Argentina
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Corrientes, , Argentina
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Córdoba, , Argentina
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Paraná, , Argentina
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Rosario, , Argentina
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San Miguel de Tucumán, , Argentina
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Santa Fe, , Argentina
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Blacktown, , Australia
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Burwood, , Australia
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Castle Hill, , Australia
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Coorparoo, , Australia
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Corio, , Australia
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Cowra, , Australia
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Edmonton, , Australia
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Forbes, , Australia
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Garran, , Australia
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Ipswich, , Australia
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Melbourne, , Australia
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Sherwood, , Australia
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Smithfield, , Australia
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South Lake, , Australia
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Feldbach, , Austria
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Graz, , Austria
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Innsbruck, , Austria
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Linz, , Austria
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Salzburg, , Austria
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Sankt Veit im Pongau, , Austria
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Stankt Stefan Ob Stainz, , Austria
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Vienna, , Austria
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Bahrain, , Bahrain
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Belo Horizonte, , Brazil
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Brasília, , Brazil
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Campina Grande do Sul, , Brazil
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Campinas, , Brazil
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Curitiba, , Brazil
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Fortaleza, , Brazil
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Juiz de Fora, , Brazil
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Porto Alegre, , Brazil
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Rio de Janeiro, , Brazil
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Santa Maria, , Brazil
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São José do Rio Preto, , Brazil
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São José dos Campos, , Brazil
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São Paulo, , Brazil
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Beijing, , China
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Changsha, , China
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Chengdu, , China
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Chenzhou, , China
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Chongqing, , China
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Fuzhou, , China
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Guangzhou, , China
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Guiyang, , China
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Hefei, , China
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Kunming, , China
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Lanzhou, , China
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Nanjing, , China
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Panjin, , China
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Shanghai, , China
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Shantou, , China
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Shijiazhuang, , China
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Shiyan, , China
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Suzhou, , China
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Tianjin, , China
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Ürümqi, , China
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Wuhan, , China
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Wuxi, , China
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Barranquilla, , Colombia
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Bogotá, , Colombia
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Cali, , Colombia
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Manizales, , Colombia
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Medellín, , Colombia
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Cartago, , Costa Rica
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Heredia, , Costa Rica
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San José, , Costa Rica
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Benátky nad Jizerou, , Czechia
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Beroun, , Czechia
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Broumov, , Czechia
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Dolní Břežany, , Czechia
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Karlovy Vary, , Czechia
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Krnov, , Czechia
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Litoměřice, , Czechia
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Náchod, , Czechia
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Olomouc, , Czechia
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Ostrava, , Czechia
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Pilsen, , Czechia
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Prague, , Czechia
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Uherské Hradiště, , Czechia
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Újezd u Brna, , Czechia
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Al Mansurah, , Egypt
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Alexandria, , Egypt
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Asyut, , Egypt
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Cairo, , Egypt
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Giza, , Egypt
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Heliopolis, , Egypt
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Minya, , Egypt
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Tanta, , Egypt
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Bangalore, , India
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Chandigarh, , India
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Chennai, , India
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Coimbatore, , India
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Delhi, , India
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Ghaziabad, , India
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Gurgaon, , India
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Hyderabad, , India
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Indore, , India
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Jaipur, , India
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Kanpur, , India
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Karnāl, , India
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Kolkata, , India
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Mangalore, , India
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Mumbai, , India
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Nagpur, , India
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Noida, , India
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Pune, , India
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Trivandrum, , India
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Balikpapan, , Indonesia
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Banda Aceh, , Indonesia
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Batu, , Indonesia
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Bekasi Timur, , Indonesia
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Denpasar, , Indonesia
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Jakarta, , Indonesia
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Malang, , Indonesia
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Manado, , Indonesia
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Padang, , Indonesia
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Foggia, , Italy
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Garbagnate Milanese, , Italy
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Livorno, , Italy
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Mariano Comense, , Italy
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Parma, , Italy
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Pavia, , Italy
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Pisa, , Italy
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Potenza, , Italy
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Rimini, , Italy
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Roma, , Italy
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Sesto San Giovanni, , Italy
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Amman, , Jordan
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Az Zarqaa, , Jordan
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Irbid, , Jordan
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Kuwait City, , Kuwait
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Beirut, , Lebanon
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Byblos, , Lebanon
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Chtoura, , Lebanon
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Hamra, , Lebanon
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Mazraat Yachouaa, , Lebanon
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Saida, , Lebanon
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Tripoli, , Lebanon
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Tyre, , Lebanon
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Alor Star, , Malaysia
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Ayer Itam, , Malaysia
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Ipoh, , Malaysia
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Johor Bahru, , Malaysia
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Kelantan, , Malaysia
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Kuala Krai, , Malaysia
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Masjid Tanah, , Malaysia
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Miri, , Malaysia
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Perak, , Malaysia
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Sandakan, , Malaysia
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Seremban, , Malaysia
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Acapulco de Juárez, , Mexico
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Aguascalientes, , Mexico
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Chihuahua City, , Mexico
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Guadalajara, , Mexico
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México, , Mexico
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Monterrey, , Mexico
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San Juan del Río, , Mexico
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Tamaulipas, , Mexico
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Zapopan, , Mexico
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Almelo, , Netherlands
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Alpen Aan Den Rijn, , Netherlands
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Amersfoort, , Netherlands
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Amsterdam, , Netherlands
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De Bilt, , Netherlands
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Doetinchem, , Netherlands
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Dordrecht, , Netherlands
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Dorst, , Netherlands
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Elst, , Netherlands
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Enschede, , Netherlands
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Etten-Leur, , Netherlands
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Garderen, , Netherlands
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Geleen, , Netherlands
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Gouda, , Netherlands
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Hoogezand, , Netherlands
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Katwijk, , Netherlands
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Kerkrade, , Netherlands
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Kloosterhaar, , Netherlands
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Landgraaf, , Netherlands
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Luttenberg, , Netherlands
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Nijverdal, , Netherlands
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Oisterwijk, , Netherlands
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Roermond, , Netherlands
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Soerendonk, , Netherlands
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Steenbergen, , Netherlands
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The Hague, , Netherlands
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Utrecht, , Netherlands
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Vaassen, , Netherlands
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Voerendaal, , Netherlands
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Wamel, , Netherlands
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Zoetermeer, , Netherlands
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Zundert, , Netherlands
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Muscat, , Oman
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Calle, , Panama
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Coclé, , Panama
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Chorzów, , Poland
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Elblag, , Poland
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Gdansk, , Poland
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Katowice, , Poland
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Krakow, , Poland
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Lodz, , Poland
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Lublin, , Poland
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Parczew, , Poland
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Rzeszów, , Poland
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Zabrze, , Poland
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Zgierz, , Poland
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Arkhangelsk, , Russia
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Barnaul, , Russia
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Moscow, , Russia
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Nizhny Novgorod, , Russia
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Novosibirsk, , Russia
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Rostov-on-Don, , Russia
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Saint Petersburg, , Russia
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Saratov, , Russia
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Sestroretsk, , Russia
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Stavropol, , Russia
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Yaroslavl, , Russia
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Abhā, , Saudi Arabia
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Al Jouf, , Saudi Arabia
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Jeddah, , Saudi Arabia
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Khamis Mushait, , Saudi Arabia
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Riyadh, , Saudi Arabia
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Alberton, , South Africa
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Cape Town, , South Africa
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Durban, , South Africa
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eMkhomazi, , South Africa
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Johannesburg, , South Africa
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Lenasia, , South Africa
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Merebank, , South Africa
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Midstream, , South Africa
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Moloto South, , South Africa
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Port Elizabeth, , South Africa
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Pretoria, , South Africa
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Bucheon-si, , South Korea
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Cheonan-si, , South Korea
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Chuncheon, , South Korea
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Daejeon, , South Korea
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Goyang-si, , South Korea
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Gwangmyeong, , South Korea
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Iksan, , South Korea
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Jeju Special Self-Governing Province, , South Korea
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Seongnam-si, , South Korea
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Seoul, , South Korea
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Barcelona, , Spain
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Cadiz, , Spain
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Elche, , Spain
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Espinardo, , Spain
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Madrid, , Spain
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Móstoles, , Spain
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Salamanca, , Spain
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Sanlúcar de Barrameda, , Spain
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Segovia, , Spain
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Seville, , Spain
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Valencia, , Spain
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Changhua, , Taiwan
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Kaohsiung City, , Taiwan
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New Taipei City, , Taiwan
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Taichung, , Taiwan
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Tainan City, , Taiwan
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Taipei, , Taiwan
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Gabès, , Tunisia
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Kairaouane, , Tunisia
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Mahdia, , Tunisia
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Montfleury, , Tunisia
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Mutuelleville, , Tunisia
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Nabeul, , Tunisia
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Sfax, , Tunisia
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Sousse, , Tunisia
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Sukrah, , Tunisia
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Tunis, , Tunisia
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Tunis Belvedere, , Tunisia
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Adana, , Turkey (Türkiye)
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Afyonkarahisar, , Turkey (Türkiye)
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Antalya, , Turkey (Türkiye)
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Çanakkale, , Turkey (Türkiye)
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Çorum, , Turkey (Türkiye)
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Denizli, , Turkey (Türkiye)
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Diyarbakır, , Turkey (Türkiye)
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Düzce, , Turkey (Türkiye)
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Elâzığ, , Turkey (Türkiye)
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Gaziantep, , Turkey (Türkiye)
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Hatay, , Turkey (Türkiye)
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Istanbul, , Turkey (Türkiye)
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Izmir, , Turkey (Türkiye)
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Karaman, , Turkey (Türkiye)
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Kayseri, , Turkey (Türkiye)
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Samsun, , Turkey (Türkiye)
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Abu Dhabi, , United Arab Emirates
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Dubai, , United Arab Emirates
Countries
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References
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Al Rubeaan K, Banah F, Alruwaily FG, Sheshah E, Alnaqeb D, AlQahtani AM, Ewais D, Al Juhani N, Hassan AH, Youssef AM. Metabolic control and incidence of hypoglycaemia, hospitalisation and complications among Saudi patients with type 2 diabetes initiating second-line therapy: an analysis of the Saudi Arabia data from the DISCOVER Observational Study programme. BMJ Open. 2023 Aug 30;13(8):e063586. doi: 10.1136/bmjopen-2022-063586.
Al-Rubeaan K, Banah F, Alruwaily FG, Sheshah E, Alnaqeb D, AlQahtani AM, Ewais D, Al Juhani N, Hassan AH, Youssef AM. Longitudinal assessment of the quality of life and patterns of antidiabetic medication use in patients with type 2 diabetes, Saudi Arabia perspective, DISCOVER study. Curr Med Res Opin. 2023 Jan;39(1):27-35. doi: 10.1080/03007995.2022.2144052. Epub 2022 Nov 28.
Mita T, Katakami N, Takahara M, Kawashima M, Wada F, Akiyama H, Morita N, Kidani Y, Yajima T, Shimomura I, Watada H. Changes in Treatment Satisfaction Over 3 Years in Patients With Type 2 Diabetes After Initiating Second-line Treatment. J Clin Endocrinol Metab. 2022 Aug 18;107(9):2424-2432. doi: 10.1210/clinem/dgac420.
Hejjaji V, Gorgojo-Martinez JJ, Tang F, Garnelo JB, Cooper A, Medina J, Mutiozabal MS, Khunti K, Nicolucci A, Shestakova MV, Ji L, Gomes MB, Watada H, Vora J, Malik AO, Kosiborod M, Arnold SV. Factors associated with weight loss in people with overweight or obesity living with type 2 diabetes mellitus: Insights from the global DISCOVER study. Diabetes Obes Metab. 2022 Sep;24(9):1734-1740. doi: 10.1111/dom.14745. Epub 2022 May 25.
Khunti K, Gomes MB, Kosiborod M, Nicolucci A, Pocock S, Rathmann W, Shestakova MV, Shimomura I, Watada H, Chen H, Cid-Ruzafa J, Fenici P, Hammar N, Tang F, Ji L; DISCOVER Scientific Committee and all DISCOVER investigators. Metformin discontinuation in patients beginning second-line glucose-lowering therapy: results from the global observational DISCOVER study programme. BMJ Open. 2020 Aug 30;10(8):e034613. doi: 10.1136/bmjopen-2019-034613.
Wang JS, Chen H, Tang F, Sheu WH. Associations of fear of hypoglycemia with second-line use of insulin secretagogues or insulin and subsequent glycemic control in patients with type 2 diabetes: An analysis using data from the DISCOVER study. Int J Clin Pract. 2020 Jun;74(6):e13485. doi: 10.1111/ijcp.13485. Epub 2020 Feb 11.
Khunti K, Chen H, Cid-Ruzafa J, Fenici P, Gomes MB, Hammar N, Ji L, Kosiborod M, Pocock S, Shestakova MV, Shimomura I, Tang F, Watada H, Nicolucci A; DISCOVER investigators. Glycaemic control in patients with type 2 diabetes initiating second-line therapy: Results from the global DISCOVER study programme. Diabetes Obes Metab. 2020 Jan;22(1):66-78. doi: 10.1111/dom.13866. Epub 2019 Oct 1.
Nicolucci A, Charbonnel B, Gomes MB, Khunti K, Kosiborod M, Shestakova MV, Shimomura I, Watada H, Chen H, Cid-Ruzafa J, Fenici P, Hammar N, Surmont F, Tang F, Pocock S. Treatment patterns and associated factors in 14 668 people with type 2 diabetes initiating a second-line therapy: Results from the global DISCOVER study programme. Diabetes Obes Metab. 2019 Nov;21(11):2474-2485. doi: 10.1111/dom.13830. Epub 2019 Aug 5.
Khunti K, Ji L, Medina J, Surmont F, Kosiborod M. Type 2 diabetes treatment and outcomes worldwide: A short review of the DISCOVER study programme. Diabetes Obes Metab. 2019 Nov;21(11):2349-2353. doi: 10.1111/dom.13817. Epub 2019 Jul 14.
Kosiborod M, Gomes MB, Nicolucci A, Pocock S, Rathmann W, Shestakova MV, Watada H, Shimomura I, Chen H, Cid-Ruzafa J, Fenici P, Hammar N, Surmont F, Tang F, Khunti K; DISCOVER investigators. Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program). Cardiovasc Diabetol. 2018 Nov 28;17(1):150. doi: 10.1186/s12933-018-0787-8.
Related Links
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Other Identifiers
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D1690R00002
Identifier Type: -
Identifier Source: org_study_id
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