Combined Spinal Epidural Anesthesia and General Anesthesia for Laparoscopic Cholecystectomy

NCT ID: NCT02317510

Last Updated: 2016-03-15

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-12-31

Study Completion Date

2015-05-31

Brief Summary

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The aim of this study was to compare general anesthesia (GA) and combined (epidural and spinal) anesthesia (CA) for laparoscopic cholecystectomy. General anesthesia is a gold standard for laparoscopic cholecystectomy(LC). The use of combined anesthesia may offer several advantages over general anesthesia.

Fifty patients will be randomly assigned to either the CA LC (25 patients) or GA LC (25 patients). All patients has symptomatic gall stone disease or polyp of gall bladder. Intraoperative events related to combined anesthesia , postoperative complications, pain score and duration of operation time will record.

Detailed Description

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Objective of study : The aim of this study was to compare general anesthesia (GA) and combined (epidural and spinal) anesthesia (CA) for laparoscopic cholecystectomy. General anesthesia is a gold standard for laparoscopic cholecystectomy(LC). The use of combined anesthesia may offer several advantages over general anesthesia.

Material and methods : Fifty patients will be randomly assigned to either the CA LC (25 patients) or GA LC (25 patients). All patients has symptomatic gall stone disease or polyp of gall bladder. Intraoperative events related to combined anesthesia : abdominal discomfortable, shoulder pain, abdominal pain, nausea, anxiety, dermatomal level of sensory blockade, respiratory depression. We compare between two group; shoulder pain, postoperative complications, pain score, duration of operation time and length of hospital stay.

Fifty patients will select prospectively for LC, under low pressure (10 mm Hg) pneumoperitoneum and under combined anesthesia and general anesthesia. Spinal anaesthesia was performed at L1-L2 interspace using 2 ml of 0.5% (10 mg) hyperbaric Bupivacaine mixed with 0.5ml (25 micrograms) of Fentanyl. Epidural catheter was inserted at L1- L2 interspace too.

Conditions

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Gall Stone Disease Polyp

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

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group 1

Laparoscopic cholecystectomy in General Anesthesia

Group Type ACTIVE_COMPARATOR

combined anesthesia

Intervention Type PROCEDURE

Combined Spinal Epidural Anesthesia for laparoscopic cholecystectomy

group 2

Laparoscopic cholecystectomy in combined anesthesia (Spino epidural).

Group Type ACTIVE_COMPARATOR

general anesthesia

Intervention Type PROCEDURE

General anesthesia for laparoscopic cholecystectomy

Interventions

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combined anesthesia

Combined Spinal Epidural Anesthesia for laparoscopic cholecystectomy

Intervention Type PROCEDURE

general anesthesia

General anesthesia for laparoscopic cholecystectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Gall stone disease, polyp

Exclusion Criteria

* Gall bladder cancer
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Haseki Training and Research Hospital

OTHER

Sponsor Role collaborator

Lütfiye Nuri Burat Government Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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TURGUT DONMEZ

Medical Doctor, General Surgeon

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Turgut Donmez, operator MD

Role: PRINCIPAL_INVESTIGATOR

Lutfiye NBGH

Locations

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Lutfiye NBGH

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Bessa SS, Katri KM, Abdel-Salam WN, El-Kayal el-SA, Tawfik TA. Spinal versus general anesthesia for day-case laparoscopic cholecystectomy: a prospective randomized study. J Laparoendosc Adv Surg Tech A. 2012 Jul-Aug;22(6):550-5. doi: 10.1089/lap.2012.0110. Epub 2012 Jun 11.

Reference Type BACKGROUND
PMID: 22686181 (View on PubMed)

Other Identifiers

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HASEKI-156

Identifier Type: -

Identifier Source: org_study_id

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