Attention Bias Modification for Transdiagnostic Anxiety

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2018-01-31

Brief Summary

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This project seeks to identify neural mechanisms underlying the tendency for anxious individuals to pay more attention to threatening information than to other types of information. A computerized treatment designed to train individuals to reduce their attention towards threat will be tested, with a focus on understanding the aspects of brain function that predict response to the treatment. This work could ultimately lead to the ability to treat anxiety more effectively by directly targeting the aspects of brain function that are altered in a given patient.

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Detailed Description

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Conditions

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Anxiety Anxiety Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Completer analyses focused on prediction of active ABM outcomes using neural measures. Control arm used for effect size comparisons.

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Computerized Attention Bias Modification

Group Type EXPERIMENTAL

Attention Bias Modification

Intervention Type BEHAVIORAL

Excessive attention to threat is theorized to be a critical contributor to chronic anxiety symptoms and related negative health consequences. Attention Bias Modification, which directly targets this mechanism, is a highly cost-effective intervention with growing empirical support for its potential efficacy in clinically anxious populations.

Computerized Neutral Training

Group Type SHAM_COMPARATOR

Neutral Training

Intervention Type BEHAVIORAL

A control version of computerized attention training.

Interventions

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Attention Bias Modification

Excessive attention to threat is theorized to be a critical contributor to chronic anxiety symptoms and related negative health consequences. Attention Bias Modification, which directly targets this mechanism, is a highly cost-effective intervention with growing empirical support for its potential efficacy in clinically anxious populations.

Intervention Type BEHAVIORAL

Neutral Training

A control version of computerized attention training.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Participants will:

1. be between the ages of 18 and 55 years,
2. score \>45 on the Spielberger State-Trait Anxiety Inventory-trait form.
3. score \>=75th percentile on the World Health Organization Disability Assessment Schedule 2.0

3. currently suicidal or at risk for harm to self or others,
4. visual disturbance (\<20/40 as per the Snellen test, corrective lenses allowed)
5. \<6th grade reading level as per the Wide Range Achievement Test
6. presence of bipolar, psychotic, autism spectrum, substance dependence, or primary depressive disorder
7. positive urine drug test