Randomized Clinical Trial of Pneumatic Compression Device for the Treatment of Venous Ulcers and Lymphedema

NCT ID: NCT02284373

Last Updated: 2020-03-13

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2014-10-31

Brief Summary

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The purpose of this study is to evaluate the effect of pneumatic compression in improving symptoms, quality of life and wound healing in patients with venous ulcers and/or lymphedema.

Detailed Description

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This investigation is a randomized clinical trial of a prospective cohort of an estimated 140 subjects with venous ulcers, with an observational cohort of 50 subjects with lymphedema. Venous ulcer subjects will be randomized into two arms:

Randomization Arm 1: 70 subjects with venous ulcers will receive pneumatic compression with the Flexitouch® for the duration of one month in addition to routine care of venous ulcers and lymphedema. A pre- and post-PCD treatment CIVIQ-2 quality of life questionnaire will be administered to the subjects. For subjects with venous ulcers, wound area pre- and post-treatment will be recorded.

Randomization Arm 2: 70 subjects with venous ulcers will receive routine care of venous ulcers and lymphedema. A quality of life questionnaire will be administered at enrollment and again after one month. For subjects with venous ulcers, wound area pre- and post-treatment will be recorded.

Observational Arm 3: 50 subjects with lymphedema will ALL receive PCD treatment. A pre-and post- PCD treatment CIVIQ-2 QOL questionnaire will be administered to all subjects at enrollment and again after one month of treatment.

Conditions

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Lymphedema

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This investigation is a randomized clinical trial of a prospective cohort of subjects with venous ulcers, with an observational cohort of 50 subjects with lymphedema. Venous ulcer subjects will be randomized into two arms
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Randomization Arm 1:

70 subjects with venous ulcers will receive pneumatic compression with the Flexitouch® for the duration of one month in addition to routine care of venous ulcers and lymphedema. A pre- and post-PCD treatment CIVIQ-2 quality of life questionnaire will be administered to the subjects. For subjects with venous ulcers, wound area pre- and post-treatment will be recorded

Group Type OTHER

Flexitouch for 1 month in addition to routine wound care

Intervention Type OTHER

simultaneous wound care and pneumonic compression

Randomization Arm 2:

70 subjects with venous ulcers will receive routine care of venous ulcers and lymphedema. A quality of life questionnaire will be administered at enrollment and again after one month. For subjects with venous ulcers, wound area pre- and post-treatment will be recorded.

Group Type OTHER

Routine wound care for venous ulcers and lymphedema

Intervention Type OTHER

wound care /dressings

Observational Arm 3

50 subjects with lymphedema will ALL receive PCD treatment. A pre-and post- PCD treatment CIVIQ-2 QOL questionnaire will be administered to all subjects at enrollment and again after one month of treatment.

Group Type OTHER

Flexitouch pneumonic compression

Intervention Type DEVICE

pneumonic compression only

Interventions

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Flexitouch for 1 month in addition to routine wound care

simultaneous wound care and pneumonic compression

Intervention Type OTHER

Routine wound care for venous ulcers and lymphedema

wound care /dressings

Intervention Type OTHER

Flexitouch pneumonic compression

pneumonic compression only

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Presence of a venous ulcer on the lower extremity for at least 12 weeks14 days
* Presence of lymphedema in the lower extremity for at least 14 days

Exclusion Criteria

* Pregnant women or women of childbearing potential not on contraception
* Previous use of the pneumatic compression device
* Class IV congestive heart failure
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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11-01568

Identifier Type: -

Identifier Source: org_study_id

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