Effect of 2.5 Years of Rasagiline Therapy on Progression of Cognitive Biomarkers Assessed by MRI in Parkinson's Disease.

NCT ID: NCT02278588

Last Updated: 2023-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-11-30

Study Completion Date

2017-12-31

Brief Summary

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In this investigator-initiated study, we will compare changes in brain cognitive biomarkers assessed by diffusion tensor imaging over 2.5 years among 12 patients with Idiopathic Parkinson's disease (IPD) receiving rasagiline, 20 IPD patients not receiving MAO-B inhibitors and 25 age-matched healthy controls. Will also compare the changes in Mini-Mental State Exam (MMSE) and Montreal Cognitive Assessment (MoCA) scores and plasma brain-derived neurotrophic factor (BDNF) with changes in brain cognitive biomarkers in all IPD patients and HC over 2.5 years.

Detailed Description

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Conditions

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Parkinson's Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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PD-R

Parkinson's disease receiving rasagiline

Rasagiline

Intervention Type DRUG

PD-NMAO

Parkinson's disease not receiving any MAO-B inhibitors

No interventions assigned to this group

HC

Healthy Controls

No interventions assigned to this group

Interventions

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Rasagiline

Intervention Type DRUG

Other Intervention Names

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Azilect

Eligibility Criteria

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Inclusion Criteria

IPD or HC subjects who were enrolled in a similar study about 2.5 years ago and for whom Baseline DTI data are available.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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State University of New York at Buffalo

OTHER

Sponsor Role lead

Responsible Party

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Thomas Guttuso

Associate Professor of Neurology, Obstetrics & Gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University at Buffalo

Buffalo, New York, United States

Site Status

Countries

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United States

Other Identifiers

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[616856-4]

Identifier Type: -

Identifier Source: org_study_id

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