LOIS: Long-Term Follow-Up in INSITE/SIFI

NCT ID: NCT02270203

Last Updated: 2019-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

103 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-31

Study Completion Date

2019-07-31

Brief Summary

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The purpose of this study is to evaluate the long term safety and effectiveness of SI joint fusion using the iFuse Implant System in patients with degenerative sacroiliitis (DS) and/or sacroiliac joint disruptions (SD).

Study Design: This study is extended follow-up from two ongoing multicenter prospective US clinical trials. All participants have already undergone the surgical procedure of interest (SI joint fusion with iFuse Implant System). The two ongoing trials are:

* SIFI:( Sacroiliac Joint Fusion with iFuse Implant System) a single-arm trial of patients with degenerative sacroiliitis or sacroiliac joint disruption who underwent iFuse placement, and
* INSITE(Investigation of Sacroiliac Fusion Treatment): a randomized clinical trial of the same patient population who underwent either non-surgical treatment or iFuse placement

Detailed Description

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Conditions

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Degenerative Sacroilitis Sacroiliac Joint Disruption

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Pelvic CT at 5 years post-op

Pelvic CT at 5 years post-op

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

1. Patient enrolled and treated in SIFI or patient initially randomized to iFuse and treated in INSITE. Note: Patient may be in the initial follow up period associated with SIFI or INSITE at the same time they consent for this study and "extend" their post-operative follow up.
2. Patient has signed study-specific LOIS informed consent form.
3. Patient has the necessary mental capacity to participate and is physically able to comply with study protocol requirements.

Exclusion Criteria

1. Treated with iFuse as a "crossover" in INSITE.
2. Currently pregnant or planning pregnancy within 5 years of iFuse Implant.
3. Patient is a prisoner or a ward of the state.
4. Known or suspected active drug or alcohol abuse.
5. Inadequately treated psychiatric illness (e.g., schizophrenia, major depression, personality disorders) that could interfere with study participation.
6. Unwilling to perform the long-term follow up requirements of this study.
7. Patient has any condition that could substantially prevent long-term follow-up.
8. Unwilling to return to site at pre-specified study visits.
Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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SI-BONE, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Daniel Cher, MD

Role: STUDY_DIRECTOR

SI-BONE, Inc.

Locations

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Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Regenerative Orthopaedics and Spine Institute

Stockbridge, Georgia, United States

Site Status

Orthopaedic Center of Southern Illinois

Mount Vernon, Illinois, United States

Site Status

Bluegrass Orthopaedics & Hand Care

Lexington, Kentucky, United States

Site Status

Columbia Orthopaedic Group

Columbia, Missouri, United States

Site Status

Oklahoma Center for Spine & Pain Solutions

Oklahoma City, Oklahoma, United States

Site Status

Allegheny Medical Center

Pittsburgh, Pennsylvania, United States

Site Status

MUSC

Charleston, South Carolina, United States

Site Status

Precision Spine Care

Tyler, Texas, United States

Site Status

Overlake Hospital Medical Center

Bellevue, Washington, United States

Site Status

Aurora Research Institute

Green Bay, Wisconsin, United States

Site Status

Integrated Spine Care

Wauwatosa, Wisconsin, United States

Site Status

Countries

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United States

References

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Darr E, Cher D. Four-year outcomes after minimally invasive transiliac sacroiliac joint fusion with triangular titanium implants. Med Devices (Auckl). 2018 Aug 29;11:287-289. doi: 10.2147/MDER.S179003. eCollection 2018.

Reference Type DERIVED
PMID: 30214322 (View on PubMed)

Other Identifiers

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300244

Identifier Type: -

Identifier Source: org_study_id

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