Sublingual Fentanyl and Procedural Burn Pain

NCT ID: NCT02241486

Last Updated: 2017-07-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

2 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2015-03-31

Brief Summary

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The purpose of this study is to examine the efficacy and safety of sublingual fentanyl spray (Subsys) for procedural pain (dressing changes/minor debridement) in patients with burn injury.

Detailed Description

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The purpose of this study is to examine the efficacy and safety of sublingual fentanyl spray (Subsys) for procedural pain (dressing changes/minor debridement) in patients with burn injury. It will be compared with a standard treatment regimen of oral morphine. The hypothesis is that the fentanyl spray will be more effective for the treatment of procedural pain in patients with burn injury.

Conditions

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Burn Pain

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Sublingual Fentanyl Spray

Examine the efficacy and safety of sublingual fentanyl spray (Subsys) for procedural pain (dressing changes/minor debridement) in patients with burn injury.

Group Type EXPERIMENTAL

Sublingual Fentanyl Spray

Intervention Type DRUG

Patients with burn injuries will receive sublingual fentanyl spray (Subsys) for procedural pain (dressing changes/minor debridement).

Interventions

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Sublingual Fentanyl Spray

Patients with burn injuries will receive sublingual fentanyl spray (Subsys) for procedural pain (dressing changes/minor debridement).

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subject capable of giving consent
* Age 18-65
* Total burn surface area greater than or equal to 5%
* Opioid tolerant
* BMI less than or equal to 35

Exclusion Criteria

* Subjects with cognitive or psychiatric impairment that would preclude study participation or compliance with protocol
* Allergy to fentanyl, morphine, naloxone
* Pregnancy, intent to become pregnant or lactating
* Evidence of burn injury to oral mucosa
* Active illicit drug use or illicit drug abuse history
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Loyola University

OTHER

Sponsor Role lead

Responsible Party

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Joseph Holtman

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Joseph R Holtman Jr, MD Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Department Anesthesiology Loyola University Medical Center

Locations

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Loyola University Medical Center Burn Unit

Maywood, Illinois, United States

Site Status

Countries

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United States

Other Identifiers

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205025

Identifier Type: -

Identifier Source: org_study_id

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