People Presenting With Neurocysticercosis in North America

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

11 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-03

Study Completion Date

2017-06-13

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Background:

\- Neurocysticercosis (NCC) is caused by tapeworms that infect people. NCC can lead to serious brain problems such as seizures, sevre headaches and difficulties with movements or sensation in the limbs. Researchers want to learn more about the different ways in which people in the United States present with this disease and how they respond to standard and newer treatments.

Objective:

\- To learn about the different forms of NCC that occurs throughout North America and how patients with these forms respond to treatment.

Eligibility:

\- Adults age 18 or older with NCC.

Design:

* Participants will be screened with:
* Medical history and physical exam.
* A computed tomography (CT) brain scan The participant will lie still on a table that slides into a large donut-shaped scanner.
* Blood drawn through an arm vein for analysis
* A magnetic resonance imaging (MRI) scan of the brain and spine. They will lay flat in a long metal cylinder as the machine makes images of the body. During the scan, participants will receive a contrast agent through an IV that allows high resolution imaging of the brain and spine
* Participants will visit the clinic at 0, 1, 2, 3, 6, 12, and 24 months (7 times), and depending on the need for monitoring, more times. Participants will receive a schedule that will explain the procedures done at each visit.
* At these visits, participants may:
* Repeat the screening procedures.
* Be asked about their NCC symptoms and their physical and mental health.
* Have a urine test.
* Take a test of their ability to concentrate, their memory and spatial recognition.
* Have a lumbar puncture, if indicated by the state and severity of infection. A needle will be inserted through the skin and into the space between the bones in the back. Cerebrospinal fluid will be removed.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Natural History of Treated Neurocysticercosis and Long-Term Outcomes

NCT00001205

Cysticercosis Neurocysticercosis

RECRUITING

Brain Tissue Swelling and Seizure Activity in Inactive Cysticercosis

NCT00001912

Cysticercosis Cysts Seizures

COMPLETED

Treatment of Patients With Active Neurocysticercosis in Eastern Africa

NCT03834337

Neurocysticercosis

COMPLETED

Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection

NCT00001645

Malaria Intestinal Worms GI Protozoa +2 more

RECRUITING

Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

NCT02945527

Neurocysticercosis

TERMINATED PHASE2/PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Neurocysticercosis (NCC) is the most common helminthic CNS infection and the main cause of adult-onset seizures in low-to-middle income countries. Studies have documented significant endemicity in Latin America, Eastern Europe, sub-Saharan Africa, India and other parts of the world. The prevalence of NCC in North America is rising as a result of increased migration of people with the disease and, occasionally, immigration of individuals with asymptomatic tapeworms. Despite the gains in knowledge and understanding of the epidemiology, pathophysiology, diagnosis, and treatment, clinical care continues to be hampered by unanswered fundamental questions related to optimal diagnosis, staging, treatment, and follow-up of patients with NCC.

This multi-center, natural history study seeks to characterize: the frequency of the various forms of NCC in North American populations; the spectrum of treatment and management strategies across the North American Cysticercosis Consortium; and the response to therapy by evaluating a number of endpoints related to disease evolution and treatment, such as burden of disease, cognitive changes, radiographic changes, and treatment complications. This study will inform future research studies needed to eventually establish standardized management protocols for each form of this complex infection.

Subjects will have visits at screening, baseline, 1, 2 (optional), 3, 6, 12, and 24 months. Evaluations will include assessment of clinical status, antigen assays, radiographic imaging, functional assessments, immunologic evaluations, cognitive assessments, and quality of life measures. Additional clinically indicated visits may be scheduled as needed. This study does not provide any interventional therapies but will collect data on the course of treatment. Diagnostic examinations, consultations and medical treatment will be determined by the study clinician. Any samples removed for medical indications related to NCC may be evaluated for research purposes.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neurocysticercosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Adults greater than or equal to18 years of age.
2. Subject, or Subject s Legally Authorized Representative (LAR)/ Durable Power of Attorney (DPA), is able to provide informed consent and agree to allow samples to be stored for future research.
3. Previously or currently diagnosed with definitive or probable NCC by a practitioner at NACC in accordance with the Del Brutto criteria modified for use in a North American populations.

For the purpose of this study, definitive and probable diagnostic certainty based on presence of criteria below.

Definitive diagnosis

1. Presence of 1 absolute criterion
2. Presence of 2 major + 1 minor + 1 epidemiological criterion

Probable diagnosis Presence of 1 major + 2 minor criterion

1. Presence of 1 major + 1 minor + 1 epidemiological criterion
2. Presence of characteristic calcification(s)

Del Brutto Diagnostic criteria

1. Absolute criteria

1. Biopsy of a brain or spinal cord lesion
2. Cystic lesion with scolex on CT or MRI
3. Fundoscopic examination (subretinal parasites)
2. Major criteria

1. Highly suggestive lesions on neuroimaging
2. Positive serum enzyme-linked immunotransfer blot (EITB) assay
3. Resolution of intracranial cysts after therapy
4. Spontaneous resolution of small single enhancing lesions
3. Minor criteria

1. Compatible lesions on neuroimaging
2. Clinical manifestations suggestive for NCC (eg, headaches, seizures, neurological symptoms)
3. Positive CSF ELISA for specific Ag/Ab
4. Cysts outside CNS
4. Epidemiological criteria

1. Evidence of household contact with T. solium
2. Individuals coming from/living in endemic areas
3. History of frequent travel to endemic areas
5. Single or multiple characteristic calcifications in subjects who meet epidemiologic criteria (4) without another identifiable etiology will be considered NCC in the case of calcified granulomas

Exclusion Criteria

1\. Subjects that in the opinion of the investigator have contraindications for participation in the study will be excluded, such as patients with current substance abuse or patients currently undergoing cancer chemotherapy.

Justification for Exclusion or Inclusion of Special Populations

Children

Children are eligible to participate in this clinical trial but will not be enrolled at the NIH because the NIH investigators do not see nor specialize in pediatric populations. In addition, NCC in the U.S. generally afflicts travelers and immigrants and is therefore exceedingly rare in pediatric populations in the U.S.

Adults Unable To Provide Consent-

Patients will be offered standard of care treatment delivered irrespective of cognitive status, including lumbar punctures that are used clinical management decisions as determined by the site PI. Exclusion of patients unable to provide consent because of cognitive impairment would limit the study population significantly, and potentially compromise the generalizability of results from this observational study. In cases where cognitive function precludes informed consent we will seek consent from the designated legal guardian.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No