Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-05-31

Study Completion Date

2014-06-30

Brief Summary

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Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.

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Detailed Description

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Conditions

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Traumatic Brain Injury

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Traumatic brain injury

Patients delivered within 4 h whose highest abbreviated injury score (AIS) was 3 or less (other than head injury) were considered to be isolated traumatic brain injury cases and were included in this study.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury)
* Patients who delivered to hospital within 4 h

Exclusion Criteria

* Patients who suffered open injuries
* Patients who had existing prior neurological disease
* Patients whose serial serum samples could not be obtained
* Patients less than 18 years of age
* Patients who suffered severe life-threatening injury to organs other than the brain

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No