Improving Memory Performance by Applying Cognitive Training
NCT ID: NCT02216591
Last Updated: 2017-06-28
Study Results
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View full resultsBasic Information
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COMPLETED
NA
33 participants
INTERVENTIONAL
2014-08-31
2016-06-29
Brief Summary
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1. Investigate the effects of the cognitive training intervention on working memory and delay discounting in HIV-infected persons.
Hypothesis 1: Participants assigned to active cognitive training, compared to those in the attention-matched control group, will have greater improvements in working memory and reductions in delay discounting.
2. Characterize adherence to antiretroviral medications in this population and examine medication adherence after cognitive training.
Hypothesis 2: Participants assigned to active cognitive training, compared to those in the attention-matched control group, will have greater improvements in medication adherence.
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Detailed Description
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The research design includes two parts: an eligibility screening and the Cognitive Training study. In Part 1, Eligibility Screening, participants will complete a 2-3 hour battery of standardized measures to assess for study eligibility. Eligible individuals will then be invited to enroll in Part 2, Cognitive Training Study. Part 1 of the study will involved screening approximately 60 participants, with an estimated eligibility rate of 67% for Part 2. In Part 2, participants will be assigned to one of two groups (active cognitive training or control training; 20 participants per group) and will complete 12 training sessions over 10 weeks. Participants assigned to the active cognitive training group will complete computerized modules designed to enhance working memory, while those assigned to the attention-matched control group will complete inactive modules that are not designed to enhance memory. All Part 2 participants will complete assessments at baseline and post-training to evaluate the impact of the training program.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Active Cognitive Training (ACT)
The ACT group will complete 12 individual sessions across 6-10 weeks. Sessions will utilize four commercially available memory-training programs from PSSCogRehab 2012, published by Psychological Software Service. The four programs used will be: (1) Sequence recall of digits - auditory (SRD-A), (2) Sequenced Recall Reversed Digits - Auditory (SRRD-A), (3) Sequenced Recall of Words - Visual (SRW-V), and (4) Verbal memory - categorizing (VM-C). In each training session, participants will complete each of the four memory training programs twice.
Active Cognitive Training (ACT)
Control (CON)
The CON group will also complete 12 total sessions across 6-10 weeks. The same four computer programs from PSSCogRehab 2012, published by Psychological Software Service, will be used in the control group sessions. However, the control program will identify the correct responses to participants, such that they do not need to engage their working memory to answer the questions correctly.
Control (CON)
Interventions
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Active Cognitive Training (ACT)
Control (CON)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Currently on treatment with antiretroviral medications for \> 3 months
* Self-reported medication adherence at less than 90%
* Lives within 15 miles of the research site in stable housing and with no plans to move from the area in the next 3 months
Exclusion Criteria
* Any drug use other than alcohol or marijuana in the past year
* Pregnancy
* English non-fluency or illiteracy
* ≤ 8th grade education
* serious neurological disorders, including HIV dementia
* traumatic brain injury
* severe mental illness or acute psychiatric distress
* impaired mental status
18 Years
60 Years
ALL
No
Sponsors
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Duke University
OTHER
Responsible Party
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Principal Investigators
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Sheri L Towe, PhD
Role: PRINCIPAL_INVESTIGATOR
Duke University
Locations
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Duke University Medical Center
Durham, North Carolina, United States
Countries
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References
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Bickel WK, Yi R, Landes RD, Hill PF, Baxter C. Remember the future: working memory training decreases delay discounting among stimulant addicts. Biol Psychiatry. 2011 Feb 1;69(3):260-5. doi: 10.1016/j.biopsych.2010.08.017. Epub 2010 Oct 20.
Lovejoy TI, Suhr JA. The relationship between neuropsychological functioning and HAART adherence in HIV-positive adults: a systematic review. J Behav Med. 2009 Oct;32(5):389-405. doi: 10.1007/s10865-009-9212-9. Epub 2009 Mar 17.
Other Identifiers
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Pro00053630
Identifier Type: -
Identifier Source: org_study_id
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