SPECTAlung: Screening Patients With Thoracic Tumors for Efficient Clinical Trial Access

NCT ID: NCT02214134

Last Updated: 2025-08-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

539 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-05-22

Study Completion Date

2021-05-12

Brief Summary

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SPECTAlung is a program aiming at screening patients with thoracic tumors to identify the molecular characteristics of their disease. The thoracic tumors include lung cancer, malignant pleural mesothelioma, thymoma or thymic carcinoma at any stage. Once the molecular characteristics are identified, there might be the possibility to offer these patients access to targeted clinical trials.

Detailed Description

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Conditions

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Any Stage of Lung Cancer (Any Histotype) Any Stage of Malignant Pleural Mesothelioma Any Stage of Any Thymic Malignancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Lung cancer

Patients with diagnosis of lung cancer at any stage

Tumour markers testing

Intervention Type GENETIC

Malignant pleural mesothelioma

Patients with diagnosis of malignant pleural mesothelioma at any stage

Tumour markers testing

Intervention Type GENETIC

Thymic malignancy

Patients with diagnosis of thymic malignancy at any stage

Tumour markers testing

Intervention Type GENETIC

Interventions

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Tumour markers testing

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Pathologically confirmed lung cancer, MPM, thymoma or thymic carcinoma at any stage;
* Mandatory availability of adequate Human Biological Material (HBM): FFPE tissue sample from the primary tumor, recurrent tumor, metastasis, obtained at the time of primary surgery or biopsy; minimal amount requested is detailed in the HBM guidelines; inclusion of samples taken at any recurrence diagnosed during follow-up is strongly encouraged but optional;
* Centrally performed confirmation of tumor tissue adequacy in terms of quality/ quantity for central screening;
* Age ≥ 18 years;
* At least three months life-expectancy;
* Written informed consent according to ICH/GCP and national/local regulations.

Exclusion Criteria

* Any active malignancy, except pT1-2 prostatic cancer Gleason score \< 6, non melanomatous skin cancer or carcinoma in situ of the cervix, in the 5 years before study entry;
* Active hepatitis B/C or HIV;
* Any secondary malignancy;
* Any severe organ dysfunction or other comorbidities that may prevent the inclusion into clinical trials.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ETOP IBCSG Partners Foundation

NETWORK

Sponsor Role collaborator

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Benjamin Besse, MD, PhD

Role: STUDY_CHAIR

Gustave Roussy, Cancer Campus, Grand Paris

Locations

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Hopitaux Universitaires Bordet-Erasme - Institut Jules Bordet

Brussels, , Belgium

Site Status

Universitair Ziekenhuis Antwerpen

Edegem, , Belgium

Site Status

U.Z. Leuven - Campus Gasthuisberg

Leuven, , Belgium

Site Status

CHU de Lyon - Hopital Louis Pradel

Lyon, , France

Site Status

Assistance Publique - Hopitaux de Marseille - Hopital Nord

Marseille, , France

Site Status

CHU Toulouse - Hopital Larrey

Toulouse, , France

Site Status

Gustave Roussy Cancer Campus

Villejuif, , France

Site Status

St. James's Hospital

Dublin, , Ireland

Site Status

Ospedale S. Luigi Gonzaga - Universita Di Torino

Torino, , Italy

Site Status

Medical University Of Gdansk

Gdansk, , Poland

Site Status

University Clinic Golnik

Golnik, , Slovenia

Site Status

Hospital General Vall D'Hebron

Barcelona, , Spain

Site Status

Hospital Universitario 12 De Octubre

Madrid, , Spain

Site Status

Centre Hospitalier Universitaire Vaudois - Lausanne

Lausanne, , Switzerland

Site Status

Centre Hospitalier Universitaire Vaudois - Lausanne

Lausanne, , Switzerland

Site Status

Royal Marsden Hospital - Kingston Hospital

Kingston upon Thames, , United Kingdom

Site Status

Royal Marsden Hospital - Chelsea, London

London, , United Kingdom

Site Status

Royal Marsden Hospital - Sutton, Surrey

Sutton, , United Kingdom

Site Status

Countries

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Belgium France Ireland Italy Poland Slovenia Spain Switzerland United Kingdom

Other Identifiers

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EORTC-1335-LCG-PBG

Identifier Type: -

Identifier Source: org_study_id

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