Molecular Profiling and Dynamic Changes of ctDNA in Unresectable Locally Advanced NSCLC

NCT ID: NCT05641870

Last Updated: 2022-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-01

Study Completion Date

2023-12-31

Brief Summary

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Multi-center observational clinical study to evaluate the application value of ctDNA monitoring in efficacy assessment and relapse prediction in patients diagnosed with unresectable, locally advanced NSCLC receiving CRT with or without durvalumab maintenance treatment.

Detailed Description

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Newly diagnosed, histologically confirmed, unresectable stage III NSCLC patients, amenable to receive standard of care chemoradiotherapy with or without durvalumab maintenance, will be enrolled in this study. Whole blood collection will be conducted during the treatment for ctDNA detection in specific time-points of interest. Next-generation sequencing using commercially available panels, and analysis of ctDNA aberrant methylation will be performed. Results will be correlated to patients' recurrence times and survival outcomes.

Conditions

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Lung Cancer Stage III Lung Cancer Unresectable Lung Carcinoma

Keywords

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Liquid biopsy ctDNA Chemoradiotherapy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Sample collection

Tumor samples will be collected as standard diagnostic procedure at diagnosis. Plasma samples from whole blood extractions will also be collected at diagnosis, after chemoradiotherapy, and every 3 months from there until completing one year of follow-up.

Intervention Type PROCEDURE

Characterization of the tumoral tissue genomic alterations

Genomic alterations of tumor tissue samples will be analyzed locally by next-generation sequencing when material is adequate, as standard diagnostic procedure.

Intervention Type DIAGNOSTIC_TEST

Chemoradiation treatment regimen and maintenance (if amenable)

Patients will be treated with standard chemotherapy (following the clinical practice at each institution). Radiotherapy will be delivered concurrently when feasible with a total dose of 60-66 Gy. In selected cases, due to frailty of the patient or impaired pulmonary function, radiotherapy will be delivered sequentially. In tumors with positive PD-L1 expression, a year of durvalumab 10 mg/m2 every 2 weeks will be administered if there are no contraindications.

Intervention Type DRUG

Genomic and methylation analysis in liquid biopsy

Blood samples for ctDNA genomic and methylation analysis (4 mL of plasma for each sample) will be sent to the Guardant Health Laboratories in the US and analyzed after Contractual Agreement signature, using the Guardant Reveal test.

This liquid biopsy test uses ctDNA to detect presence of MRD and monitor for recurrence after definitive surgical/systemic therapy for patients with cancer. It has been validated in early-stage colorectal cancer and integrates assessment of somatic alterations with an epigenomic cancer signature to identify the presence of methylation signatures associated with cancer versus normal DNA.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients with newly diagnosed, histologically confirmed, unresectable locally advanced NSCLC.
* ≥18 years of age.
* Ability to understand the written informed consent and willingness to sign it.

Exclusion Criteria

* Patients who are unwilling to follow-up evaluation of response to therapy.
* Any condition that, in the opinion of the investigator, would interfere with study results.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Guardant Health, Inc.

INDUSTRY

Sponsor Role collaborator

Parc de Salut Mar

OTHER

Sponsor Role lead

Responsible Party

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Edurne Arriola

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Edurne Arriola

Role: PRINCIPAL_INVESTIGATOR

Parc de Salut Mar

Locations

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Parc de Salut Mar - Hospital del Mar

Barcelona, , Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Edurne Arriola

Role: CONTACT

Phone: 932483137

Email: [email protected]

Pedro Rocha

Role: CONTACT

Phone: 932483137

Email: [email protected]

Facility Contacts

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Edurne Arriola

Role: primary

Pedro Rocha

Role: backup

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Other Identifiers

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2022/10344/I

Identifier Type: -

Identifier Source: org_study_id