Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients

NCT ID: NCT02207647

Last Updated: 2022-04-20

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-04-30
• Study Completion Date: 2021-12-31

Brief Summary

Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern. Routine clinical and laboratory evaluation of such patients involves screening for known infectious disease agents, selection of which is nonstandardized. Progress in diagnostic technologies, especially molecular techniques based on genetic characteristics of potential pathogens, has greatly expanded the investigators capacity to evaluate specimens from patients for a much wider range of potential pathogens (bacterial, viral, fungal and parasitic agents). Use of Polymerase Chain Reaction (PCR) technology offers the possibility of identifying causative agents for the approximately 50% of all such presentations which go un-diagnosed. The investigators propose a study involving a collaboration between the EMERGEncy ID NET, a network of 10 geographically diverse university-affiliated urban emergency departments (coordinated by Olive View-UCLA Medical Center) and the Centers for Disease Control and Prevention (CDC), to use these new technologies to address this issue.

Conditions

Meningoencephalitis; Other Syndromes Requiring Lumbar Puncture in Emergency Department

Study Design

• Observational Model Type: ECOLOGIC_OR_COMMUNITY
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with syndromes requiring lumbar puncture

no intervention

Intervention Type: OTHER

Interventions

no intervention

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age > or = 3 months old
• Receiving a Lumbar Puncture in the emergency department as part of their standard care.

Exclusion Criteria

• No CSF available

• Minimum Eligible Age: 3 Months
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centers for Disease Control and Prevention

FED

Sponsor Role: collaborator

Olive View-UCLA Education & Research Institute

OTHER

Sponsor Role: lead

Responsible Party

David A. Talan

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Olive View-UCLA Medical Center

Sylmar, California, United States

Countries

United States

Other Identifiers

U01CK000176

Identifier Type: NIH

Identifier Source: secondary_id

View Link

12H-770352

Identifier Type: -

Identifier Source: org_study_id