PET/MRI Imaging of Glutamate Release in the Brain

NCT ID: NCT02511691

Last Updated: 2020-08-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-07-31

Study Completion Date

2016-03-03

Brief Summary

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Based on PET (18-PSS232) and MRI, glutamate release after N-acetylcystein challenge will be monitored in human brains.

Detailed Description

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Diagnostic trial with quantification of glutamate release in PET/MR.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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18F-PSS232

Subjects receive baseline PET with 18F-PSS232 and stimulation PET with 18F-PSS232 after medical challenge with N-acetylcystein

Group Type OTHER

18F-PSS232

Intervention Type DRUG

Diagnostic PET Tracer

Interventions

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18F-PSS232

Diagnostic PET Tracer

Intervention Type DRUG

Other Intervention Names

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18FABP

Eligibility Criteria

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Inclusion Criteria

* healthy volunteer

Exclusion Criteria

* smoker
* drug addiction
* significant neurological or psychiatric conditions
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alfred Buck, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Locations

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University Hopsital Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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KEK ZH 2014-0441

Identifier Type: -

Identifier Source: org_study_id

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