Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
70 participants
INTERVENTIONAL
2014-07-31
2017-12-31
Brief Summary
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It is becoming increasingly clear that reflux, especially in the postprandial period, occurs from a reservoir of acid floating on top of the meal: the so-called "acid pocket". In this study, we aim to investigate further the acid pocket by determining its exact position and chemical contents between healthy volunteers, GERD patient who respond well and bad to PPI therapy and GERD patients with barrett's esophagus.
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Detailed Description
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The special catheter will be removed at the end of the study. Collected acid pockets will be used to analyze content and perform permeability experiments.
Data of the 24-hour experiment will be used to evaluate the position of the acid pocket and number of reflux episodes.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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healthy volunteers
healthy volunteers (no gastric complains)
multi-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
PPI responders
proven reflux, good symptom relief upon PPI therapy
multi-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
PPI non-responders
proven reflux disease, poor symptom control (less then 50% symptom reduction) upon PPI therapy (2x40mg omeprazole)
multi-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
Barrett - no dysplasia
proven barrett with no dysplasia on biopsies
multi-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
barrett - high grade dysplasia
proven barrett with high grade dysplasia on biopsies
multi-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
Interventions
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multi-pH-impedance manometry catheter
a special catheter will be placed in the esophagus of all study groups. Measurment of pH, impedance and pressure will be performed.
Eligibility Criteria
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Inclusion Criteria
* older than 18 years
* fit to criteria of 'study population' (HV, PPI responder, PPI non-responder, Barrett)
Exclusion Criteria
18 Years
80 Years
ALL
Yes
Sponsors
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KU Leuven
OTHER
Responsible Party
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Guy Boeckxstaens
MD, PhD
Principal Investigators
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Guy Boeckxstaens, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Catholic University Leuven
Locations
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Catholic University Leuven
Leuven, , Belgium
Countries
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Other Identifiers
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S55731
Identifier Type: -
Identifier Source: org_study_id
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