Study of Osteopathic Manipulative Medicine on the Autonomic Nervous System

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

126 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2018-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose this study is to determine which manual medicine technique or combination of techniques has the greatest effect on the natural changes in heart rate.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Osteopathic Manipulative Treatment and Its Relationship to Autonomic Nervous System Activity

NCT00516984

Healthy

COMPLETED NA

Physiological Responses to Osteopathic Manipulative Techniques in Healthy Young Adults

NCT05515926

Healthy Young Adults

COMPLETED NA

Effect of CV4 and Rib Raising Techniques on Autonomic Balance

NCT03142373

Autonomic Nervous System Disease Osteopathy

COMPLETED NA

Effects of Osteopathic Technique on Autonomic Nervous System Activity

NCT06554834

Healthy Dysautonomia

RECRUITING NA

Relationship Between Chiropractic Care and Autonomic Nervous System Regulation

NCT05401903

Chiropractic Maintenance Care and Heart Rate Variability

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study intends to examine how three different OMM techniques, sub-occipital release, rib-raising, and stellate ganglion release, impact autonomic nervous system tone. Subjects will be randomly assigned to one of four cohort groups, receiving either sub-occipital release, rib-raising, stellate ganglion release or all three treatment techniques. A shift towards sympathetic tone will be induced in all subjects using a tilted-to-seated-position test (Tilt-Seated Position test) and cognitive challenge test, consisting of computerized questions that become progressively more difficult, and which subjects are asked to answer as quickly and accurately as possible. These stress tests will be induced twice, once without any OMM treatment and a second time with the designated OMM treatment(s). The sympathetic-dependent response to orthostatic change and cognitive challenges will be determined by Fourier analysis of heart rate variability, recorded using an EKG attached to each subject.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Osteopathic Manual Manipulation of Neurovascular Regulation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sub-Occipital Release

Osteopathic Manual Medicine

Group Type ACTIVE_COMPARATOR

Osteopathic Manual Medicine

Intervention Type OTHER

Osteopathic Manual Medicine

Rib-Raising

Osteopathic Manual Medicine

Group Type ACTIVE_COMPARATOR

Osteopathic Manual Medicine

Intervention Type OTHER

Osteopathic Manual Medicine

Stellate Ganglion Release

Osteopathic Manual Medicine

Group Type ACTIVE_COMPARATOR

Osteopathic Manual Medicine

Intervention Type OTHER

Osteopathic Manual Medicine

All techniques

Osteopathic Manual Medicine

Group Type ACTIVE_COMPARATOR

Osteopathic Manual Medicine

Intervention Type OTHER

Osteopathic Manual Medicine

All Techniques-S

Sham Osteopathic Manual Medicine

Group Type SHAM_COMPARATOR

Sham

Intervention Type OTHER

Osteopathic Manual Medicine

Sub-Occipital Release-S

Sham Osteopathic Manual Medicine

Group Type SHAM_COMPARATOR

Sham

Intervention Type OTHER

Osteopathic Manual Medicine

Rib-Raising-S

Sham Osteopathic Manual Medicine

Group Type SHAM_COMPARATOR

Sham

Intervention Type OTHER

Osteopathic Manual Medicine

Stellate Ganglion Release -S

Sham Osteopathic Manual Medicine

Group Type SHAM_COMPARATOR

Sham

Intervention Type OTHER

Osteopathic Manual Medicine

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Osteopathic Manual Medicine

Intervention Type OTHER

Sham

Osteopathic Manual Medicine

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Sub-Occipital Release Rib-Raising Stellate Ganglion Release Sham sub-occipital release Sham stellate ganglion release Sham rib raising

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy Individual capable of giving consent between the ages of 20-50
* Normal blood pressure as defined by the Seventh Report of US National Committee on Prevention, Detection, Education and Treatment of High Blood Pressure
* Normal EKG
* Normal Heart Rate

Exclusion Criteria

* Chronic Cardiovascular Disease (including but not limited to: congestive heart failure, previous myocardial infarction, any cardiomyopathy, any arrhythmia, or previous cardiac surgery)
* Hypertension as defined by the Seventh Report of US National Committee on Prevention, Detection, Education and Treatment of High Blood Pressure or hypertensive medications
* Smoking
* Asthma
* Pregnancy
* Diabetes
* Current or recent illness (within the past 7 days)
* Any manipulative therapies within the previous 7 days (including but not limited to: osteopathic manipulative treatment, massage or acupuncture)
* Well conditioned athletes (such as long distance runners)
* Anyone who fails to have an increased heart rate with the passive tilt test (50 degrees head-up)

Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes