Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.

NCT ID: NCT02192177

Last Updated: 2014-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-08-31

Brief Summary

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Intrahepatic cholestasis of pregnancy is a disease specific to pregnancy period; especially late second and third trimester. We aimed to investigate the role of apoptosis in etiopathogenesis of obstetric cholestasis.

Detailed Description

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M30 (caspases cleaved Cytokeratin-18 (CK-18) fragment) is a specific apoptosis marker. We aimed to use it to evaluate the apoptotic process.

Conditions

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Pregnancy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

Pregnant subjects diagnosed with obstetric cholestasis who didn't have any foreknown systemic disease.

No interventions assigned to this group

Group 2

entirely healthy pregnant subjects, the control group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Late second or third trimester of pregnancy.

Exclusion Criteria

* Foreknown systemic diseases, multiple pregnancy, smoking cigarettes.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Zekai Tahir Burak Women's Health Research and Education Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ali Ozgur Ersoy

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ali O Ersoy

Role: PRINCIPAL_INVESTIGATOR

Medical doctor

Locations

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Zekai Tahir Burak Maternity Teaching Hospital

Ankara, Ankara, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Ali O Ersoy

Role: CONTACT

+905056579157

Facility Contacts

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Ali O Ersoy

Role: primary

+905056579157

References

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Del Ben M, Polimeni L, Baratta F, Bartimoccia S, Carnevale R, Loffredo L, Pignatelli P, Violi F, Angelico F. Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver. Int J Hepatol. 2014;2014:784985. doi: 10.1155/2014/784985. Epub 2014 Jan 29.

Reference Type BACKGROUND
PMID: 24678423 (View on PubMed)

Du Q, Zhang Y, Pan Y, Duan T. Lithocholic acid-induced placental tumor necrosis factor-alpha upregulation and syncytiotrophoblast cell apoptosis in intrahepatic cholestasis of pregnancy. Hepatol Res. 2014 May;44(5):532-41. doi: 10.1111/hepr.12150. Epub 2013 May 31.

Reference Type BACKGROUND
PMID: 23627780 (View on PubMed)

Other Identifiers

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M30 Intrahepatic cholestasis

Identifier Type: -

Identifier Source: org_study_id

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