Effects of Exercise and 5-HTP on Cortisol Levels

NCT ID: NCT02187341

Last Updated: 2014-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2015-12-31

Brief Summary

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It has been shown that 5-HTP stimulates cortisol levels in plasma and saliva. Similarly, it has been shown that intense exercise stimulates an increase in plasma and salivary cortisol levels. The purpose of this study is to examine the combined effects of 5-HTP + intense exercise on plasma and salivary cortisol levels.

Detailed Description

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Conditions

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Plasma Cortisol

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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5-HTP

200 mg 5-HTP capsule will be ingested 2h prior to reporting to the laboratory.

Group Type EXPERIMENTAL

5-HTP

Intervention Type DIETARY_SUPPLEMENT

Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized

Placebo

For these visit subjects will ingest placebo (Sugar pill) capsule 2 hours before reporting to the laboratory.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized

Interventions

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5-HTP

Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized

Intervention Type DIETARY_SUPPLEMENT

Placebo

Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women, not taking medication known to alter glucocorticoid metabolism

Exclusion Criteria

* Diabetes
* Obesity
* Hypertension
* Coronary artery disease
* Psychiatric disorders
* Any disease preventing them from participating in intense exercise
* Subjects taking medication known to interfere with glucocorticoid metabolism will be excluded
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Benedictine University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pedro Del Corral, PhD-MD

Role: PRINCIPAL_INVESTIGATOR

Benedictine University

Locations

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Benedictine University

Lisle, Illinois, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Pedro Del Corral, PhD-MD

Role: CONTACT

630 8296575

Other Identifiers

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Ben-0614b

Identifier Type: -

Identifier Source: org_study_id

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