Towards a Viral Etiology of Periodontal Disease in Relation to Radiotherapy Treatment of Head and Neck Cancers
NCT ID: NCT02180932
Last Updated: 2015-10-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
25 participants
INTERVENTIONAL
2014-06-30
Brief Summary
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This project proposes to deepen the investigation with two main objectives:
1. To study in vivo the effect of radiation treatment on the evolution of the viral flora of the periodontium in a cohort of patients and matched controls.
2. To study in vitro the effects of irradiation on the replication EBV (herpesvirus) in producing websites lymphoepithelial tonsillar, and atypical dendritic cells associated with EBV that existence were recently discovered.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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periodontal disease
Saliva samples
periodontal pocket samples
Interventions
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periodontal pocket samples
Eligibility Criteria
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Inclusion Criteria
* Patients treated with curative radiotherapy on tumor site or surgery for cancer of the oral cavity and / or oropharynx
* Patients naive treatments for head and neck cancers
* Patients affiliated or beneficiary of a social security scheme
* Patients who gave informed consent in writing
Exclusion Criteria
* Patients taking immunosuppressants after organ transplantation
* Taking anticoagulants incompatible with dental samples (possible bleeding)
* Patients edentulous and / or whose dental condition is incompatible with the dental samples
18 Years
80 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Nice
OTHER
Responsible Party
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Locations
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Hôpital saint Roch
Nice, , France
Countries
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Other Identifiers
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13-GIRCI-01
Identifier Type: -
Identifier Source: org_study_id
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