Symptom Based Treatment of Neuropathic Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2014-08-31

Brief Summary

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1\. Neuropathic pain in spinal cord injured patients

1. Inclusion criteria

* pain intensity, visual analogue scale \> 3
* a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
* aged ≥20
2. Method

* Stop pain medications
* Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily)
* Check pain intensity (VAS score) with Baron's classification

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Detailed Description

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In the present study, pharmacologic treatment included pregabalin and oxcarbazepine.

Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain and the central nervous system prior to the study for at least 3 days.

1. Pain intensity (VAS score)

1. 4 spontaneous characters

* electric
* burning
* pricking
* numbness
2. evoked pain

* allodynia
* heat hyperalgesia
* pressure hyperalgesia
2. Location of neuropathic pain

1. neuropathic pain at level of spinal cord injury
2. neuropathic pain below level of spinal cord injury

2\. Side effects

Conditions

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Neuralgia Spinal Cord Injury

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Pregabalin and Oxcarbazpepine

Pregabalin and Oxcarbazepine

Group Type EXPERIMENTAL

Pregabalin and Oxcarbazepine

Intervention Type DRUG

Subjects will take pregabalin for the duration of 2 weeks. The dosage will be increased from 75 mg twice to 150 mg twice a day.

Subjects will stop pregabalin for 1 week and take oxcarbazepine 150mg twice.

Interventions

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Pregabalin and Oxcarbazepine

Subjects will take pregabalin for the duration of 2 weeks. The dosage will be increased from 75 mg twice to 150 mg twice a day.

Subjects will stop pregabalin for 1 week and take oxcarbazepine 150mg twice.

Intervention Type DRUG

Other Intervention Names

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Lyrica and Oxcarb

Eligibility Criteria

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Inclusion Criteria

* aged than 20 years
* Neuropathic pain symptoms : LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
* Visual analogue scale score of 3 and above