Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance

NCT ID: NCT02161471

Last Updated: 2025-03-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 22 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-06-16
• Study Completion Date: 2009-11-24

Brief Summary

The purpose of this study is to determine whether patients with repaired congenital heart disease show differences in size or function of their heart atria compared to normal controls and depending on the nature of their heart disease.

Detailed Description

Atrial function is important for good ventricular filling and function. In patients with impaired cardiac function, atrial contraction is even more important. So far, the size and function of the atria have been assessed two-dimensionally by angiography and by echocardiography. However, these do not allow exact characterization of the volumetric changes of the atria during the cardiac cycle. Recently, cardiac magnetic resonance (CMR) has been used to assess size and function of the left atrium in adults. Little data are available about function and volume of the atria in children and the role of the atria in congenital heart disease (CHD).

The study will recruit patients with CHD (n=40) and normal controls (n=10). The patient group will be composed by patients suffering from the following conditions: coarctation of the aorta (n=10), tetralogy of Fallot (n=10), transposition of the great arteries after atrial switch (Senning procedure) (n=10), transposition of the great arteries after arterial switch operation (n=10).

The study consists of measurements of sizes and function of the right and the left atrium, respectively, by examining three-dimensional volume changes across the heart cycle, and of phase contrast measurements of blood flow across the valves of the heart.

Conditions

Coarctation of the Aorta; Tetralogy of Fallot; Transposition of the Great Arteries

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Tetralogy of Fallot

Patients after repair of tetralogy of Fallot

No interventions assigned to this group

Normal

Normal controls

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Ability to perform repetitive breath holds of 10-15 seconds each
• Written informed consent of the patients or their legal guardians

Exclusion Criteria

• Patients requiring general anaesthesia
• Residual cardiac findings which might potentially influence the size and function of the atria

• Minimum Eligible Age: 8 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Children's Hospital, Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Emanuela R Valsangiacomo Buechel, Prof.

Role: PRINCIPAL_INVESTIGATOR

University Children's Hospital Zürich, Switzerland

Locations

University Children's Hospital Zürich, Switzerland

Zurich, Canton of Zurich, Switzerland

Countries

Switzerland

Other Identifiers

Atrial function in CHD by CMR

Identifier Type: -

Identifier Source: org_study_id