Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

39 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2014-12-31

Brief Summary

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The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT). Such criteria are of great clinical relevance as a growing number of patients undergo a cardiac CT scan in daily clinical routine.

The investigators aim to test the diagnostic accuracy of cardiac CT in distinguishing IVNC from lesser degrees of trabecular layering seen in potential differential diagnoses such as cardiomyopathies and left ventricular hypertrophy or dilation.

The investigators hypothesize that echocardiographic diagnosed pathological trabeculation can be distinguished by determining the ratio of non-compacted to compacted myocardium on cardiac CT.

Detailed Description

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Conditions

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Left Ventricular Noncompaction Isolated Noncompaction of the Ventricular Myocardium

Keywords

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isolated left ventricular non-compaction cardiac computed tomography cardiac magnet resonance imaging echocardiography

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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IVNC

No interventions assigned to this group

differential diagnosis to IVNC

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Established diagnosis of IVNC or differential diagnosis
* Age: Men \> 30 years, women \> 50 years without menstruation for at least 2 month.
* Written informed consent to participate

Exclusion Criteria

* Renal insufficiency (GFR \< 60ml/min)
* Known allergy to iodinated contrast agent
* Known Hyperthyroidism
* Non-sinus rhythm
* Known premature ventricular or supraventricular beats
* Hypotension (systolic blood pressure \< 100mmHg)

Contraindication for CMR

* Implanted cardiac pacemaker or defibrillator
* Other implanted medical devices (e.g. implantable cardioverter-defibrillator)
* Claustrophobia
* Known premature ventricular or supraventricular beats
* Pregnancy
* Claustrophobia

Minimum Eligible Age

30 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Felix Tanner, Prof. MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Zurich, Division of Cardiology

Locations

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Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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KEK 2011-0099

Identifier Type: -

Identifier Source: org_study_id