The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2016-05-31

Brief Summary

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Pyridostigmine is a medication that is used in certain heart rate and blood pressure conditions. This medication, as a side effect, is known to also cause changes in the junction between a nerve and muscle. The changes caused at the nerve muscle junction by pyridostigmine could alter the effect of muscle relaxants (a medication used during surgery and anesthesia). The investigators are conducting this study to see whether patients taking pyridostigmine are more or less sensitive to rocuronium (a muscle relaxing medication used during surgery).

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Detailed Description

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No subjects enrolled. No data collected.

Conditions

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Muscle Relaxants

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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pyridostigmine

administration of rocuronium to determine its potency.

No interventions assigned to this group

control arm (no pyridostigmine)

determination of potency of rocuronium in patients not taking pyridostigmine

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients who take pyridostigmine for any reason or those who are matched by age, sex and weight to subjects taking pyridostigmine
* Patients who will be administered rocuronium during elective procedures as standard clinical care.

Exclusion Criteria

* Allergy to rocuronium
* Known neuromuscular disorder, patients suffering from myasthenia gravis
* Subjects taking medications known to impact neuromuscular transmission (ex. gentamicin).

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No