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Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans

NCT ID: NCT03754842

Last Updated: 2020-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-12

Study Completion Date

2020-09-01

Brief Summary

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Successful skeletal muscle regeneration depends on a functional pool of muscle stem cells, termed satellite cells (SC). SC are in a quiescent state throughout adulthood, but undergo multiple cycles of proliferation and self-renewal in response to muscle damage. During aging, there is a loss of SC quiescence, and SC more readily enter an ageing-state impairing their function.

Animal studies have revealed a common denominator for increasing SC function and activity, namely Sirtuin activation. Natural stimulators of Sirtuins includes Nicotinamide Riboside (NR) (a Nicotinamide adenine dinucleotide (NAD+) precursor) and the polyphenol Pterostilbene (PT). In this study, we aim to investigate if NR+PT supplementation will promote skeletal muscle regeneration after muscle damage in elderly humans by enhanced recruitment of SC.

Detailed Description

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14 days after start of placebo or NR/PT (500/100 mg twice daily) supplementation a muscle damage will induced in the m. vastus lat. by electric stimulation combined with eccentric work in a dynamometer. Muscle biopsies will be collected at 2 hours, 2, 8 and 30 days post damage and placebo or NR/PT supplementation will continue for the whole study period (45 days).

Conditions

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Muscle Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Group Type PLACEBO_COMPARATOR

Placebo (twice daily)

Intervention Type OTHER

Matching placebo

Nicotinamide Riboside + Pterostilbene

Group Type EXPERIMENTAL

Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)

Intervention Type OTHER

Elysium Basis TM, Elysium Health, Inc., NY, USA

Interventions

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Placebo (twice daily)

Matching placebo

Intervention Type OTHER

Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)

Elysium Basis TM, Elysium Health, Inc., NY, USA

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Written signed consent
* Age: 55-80
* BMI: 20-28 (kg/(m2))
* Non-smoker

Exclusion Criteria

* Endocrine disease, neurological or muscle disease
* Other severe disease
* High daily activity level (\>30 min / day)
Minimum Eligible Age

55 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Copenhagen

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Aarhus University Hospital

Aarhus N, , Denmark

Site Status

Countries

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Denmark

References

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Jensen JB, Dollerup OL, Moller AB, Billeskov TB, Dalbram E, Chubanava S, Damgaard MV, Dellinger RW, Trost K, Moritz T, Ringgaard S, Moller N, Treebak JT, Farup J, Jessen N. A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals. JCI Insight. 2022 Oct 10;7(19):e158314. doi: 10.1172/jci.insight.158314.

Reference Type DERIVED
PMID: 35998039 (View on PubMed)

Other Identifiers

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AU2018-11-19

Identifier Type: -

Identifier Source: org_study_id