Study on Anal Human Papillomavirus Infection and Anal Intraepithelial Neoplasia Among Men Who Have Sex With Men in Indonesia, Malaysia, and Thailand

NCT ID: NCT02155231

Last Updated: 2024-11-25

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 430 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-02-28
• Study Completion Date: 2022-12-31

Brief Summary

OBJECTIVES

1. To determine the prevalence and incidence of anal HPV infection, including infection with high-risk HPV types, among MSM in Indonesia, Malaysia, and Thailand.

2. To study the prevalence and incidence of HGAIN among these MSM.

3. To evaluate risk factors, including HIV status, for anal high-risk HPV infection and HGAIN among these MSM.

Study population An approximately 75 HIV-positive and 75 HIV-negative MSM who attended the study clinic in Kuala Lumpur, Jakarta, and Bangkok will be enrolled. The study will also enroll 185 HIV-positive and 95 HIV-negative MSM who are previous participants of the MSM VCT study. There will be approximately 260 HIV-positive and 170 HIV-negative MSM in total in this study.

Detailed Description

This is a prospective cohort study that will newly enroll approximately 150 MSM in Kuala Lumpur, Jakarta, and Bangkok and follow them prospectively with a group of 280 MSM who are previous participants of a study entitled "Multidisciplinary services to enhance HIV testing and linkage to care among MSM" (MSM VCT study) in Jakarta, Bali, and Bangkok. Newly enrolled MSM will have three study visits at baseline, month 6, and at month 12. MSM who are previous participants of the MSM VCT study will only have one study visit.

Conditions

HPV Testing

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

previous enrolled

No interventions assigned to this group

New Enrolled

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Male with history of anal sex with men or previous participants of the MSM VCT study.

2. Age 18 years old or older.

3. Indonesian or Malaysian or Thai citizen as identified by the Indonesian or Malaysian or Thai National Identification card.

4. Willing to provide location or contact information and allow contact.

5. Available for follow-up for the planned study duration.

6. Understand the study and sign informed consent form.

Exclusion Criteria

1. History of prior treatment for anal cancer OR had anal cytology or high-resolution anoscopy or infrared coagulation within 12 months prior to enrollment OR had trichloroacetic acid or podophyllin application of the intraanal area in the past month OR evidence of active concurrent intraanal or perianal bacterial or herpes simplex infection.

2. Persons who have a history of a medical or psychiatric disorder by investigator's interview and physical examination according to standard practices, that in the judgment of the investigator(s), would interfere with ability to give informed consent.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Verein Aids Life through TREAT Asia

UNKNOWN

Sponsor Role: collaborator

Thai Red Cross AIDS Research Centre

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The Thai Red Cross AIDS Research Centre

Pathum Wan, Bangkok, Thailand

Countries

Thailand

Other Identifiers

Anal HPV and AIN among MSM

Identifier Type: -

Identifier Source: org_study_id