Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke

NCT ID: NCT02152813

Last Updated: 2019-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2018-01-31

Brief Summary

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This proposed study aims to compare the effects of unilateral and bilateral transcutaneous electrical nerve stimulation (TENS). It will compare the effectiveness of bilateral TENS + task-oriented training (TOT) with unilateral TENS+TOTin improving muscle strength, co-ordination, dynamic standing balance, walking performance, and functional mobility in patients with chronic stroke.

The null hypothesis will be that bilateral TENS+TOT and unilateral TENS+TOT are not significantly different in promoting the recovery of these functions.

Detailed Description

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This proposed study aims to compare the effects of unilateral and bilateral transcutaneous electrical nerve stimulation (TENS). It will compare the effectiveness of bilateral TENS + task-oriented training (TOT) with unilateral TENS+TOTin improving muscle strength, co-ordination, dynamic standing balance, walking performance, and functional mobility in patients with chronic stroke.

The null hypothesis will be that bilateral TENS+TOT and unilateral TENS+TOT are not significantly different in promoting the recovery of these functions.

Conditions

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Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1. Bilateral TENS (Bi-TENS) group

Subjects having bilateral electrical stimulation and task-orientated exercises

Group Type ACTIVE_COMPARATOR

TENS and Task-orientated training

Intervention Type BEHAVIORAL

All subjects will undergo 16 sessions of their assigned intervention (60 minutes, twice a week, for 8 weeks). All subjects will receive 60 minutes task-oriented lower limb training (TOT) with electrical stimulation protocol assigned concurrently:

Unilateral TENS (Uni-TENS) group

Subjects having unilateral TENS over their affected lower limb only, and task-oriented exercises

Group Type PLACEBO_COMPARATOR

TENS and Task-orientated training

Intervention Type BEHAVIORAL

All subjects will undergo 16 sessions of their assigned intervention (60 minutes, twice a week, for 8 weeks). All subjects will receive 60 minutes task-oriented lower limb training (TOT) with electrical stimulation protocol assigned concurrently:

Interventions

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TENS and Task-orientated training

All subjects will undergo 16 sessions of their assigned intervention (60 minutes, twice a week, for 8 weeks). All subjects will receive 60 minutes task-oriented lower limb training (TOT) with electrical stimulation protocol assigned concurrently:

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Subjects will be recruited from local self-help groups through poster advertising. \\
* Subjects will be included if they (1) are between 55 and 85 years of age
* Have been diagnosed with ischaemic brain injury or intracerebral hemorrhage by MRI or computed tomography within the previous 1 to 10 years
* Are able to walk 3 metres independently with or without a walking aid
* Are able to score \> 6 out of 10 on the abbreviated mental test
* Are able to follow instructions and give informed consent
* Have no skin allergy which would prevent electrical stimulation.

Exclusion Criteria

* Subjects will be excluded if they have any additional medical, cardiovascular or orthopedic condition that would hinder proper treatment or assessment
* Use a cardiac pacemaker
* Have receptive dysphasia
* Have significant lower limb peripheral neuropathy (e.g. diabetic polyneuropathy)
* Are involved in drug studies or other clinical trials.
Minimum Eligible Age

55 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Hong Kong Polytechnic University

OTHER

Sponsor Role lead

Responsible Party

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Shamay Ng

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Hong Kong Polytechnic University

Hong Kong, , Hong Kong

Site Status

Countries

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Hong Kong

References

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Kwong PWH, Ng GYF, Chung RCK, Ng SSM. Bilateral Transcutaneous Electrical Nerve Stimulation Improves Lower-Limb Motor Function in Subjects With Chronic Stroke: A Randomized Controlled Trial. J Am Heart Assoc. 2018 Feb 8;7(4):e007341. doi: 10.1161/JAHA.117.007341.

Reference Type DERIVED
PMID: 29437598 (View on PubMed)

Other Identifiers

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2014_GRF_NG

Identifier Type: -

Identifier Source: org_study_id

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