Robotic-assisted Gait Training Combined With Transcranial Direct Current Stimulation to Maximize Gait Recovery After Stroke

NCT ID: NCT01945515

Last Updated: 2016-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Brief Summary

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1. Study objective To evaluate the effect of robotic-assisted gait training combined with transcranial direct current stimulation (tDCS) as compared to that of robotic-assisted gait training on gait function of chronic stroke patients
2. Subjects chronic stroke patients with gait impairment
3. Methods

* Group 1: Robotic-assisted gait training with anodal tDCS (45 min)
* Group 2: Robotic-assisted gait training with sham tDCS (45 min)
* Duration of treatment: 2 weeks, 5 times a week
* Evaluation: Baseline, 1 day after the treatment, 4 weeks after the treatment

Detailed Description

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Conditions

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Stroke

Keywords

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Stroke transcranial direct current stimulation robotic rehabilitation gait

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Robot + anodal tDCS

Robotic-assisted gait training for 45 min after anodal tDCS on impaired motor cortex for 20 min

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

tDCS will be applied on the primary motor cortex of the lower limb in the impared hemisphere before robotic-assisted gait training. Anodal tDCS will be applied with an intensity of 2mA for 20 min. Sham tDCS will be applied with an intensity of 2mA just for 1 min, after which the current will be slowly tapered down to 0 over a several seconds.

Robotic-assisted gait training

Intervention Type DEVICE

Robotic-assisted gait training with an exoskeletal type robot which simulates normal walking on a treadmill for patients with gait impairments

Robot + sham tDCS

Robotic-assisted gait training for 45 min after sham tDCS on impaired motor cortex for 20 min

Group Type SHAM_COMPARATOR

tDCS

Intervention Type DEVICE

tDCS will be applied on the primary motor cortex of the lower limb in the impared hemisphere before robotic-assisted gait training. Anodal tDCS will be applied with an intensity of 2mA for 20 min. Sham tDCS will be applied with an intensity of 2mA just for 1 min, after which the current will be slowly tapered down to 0 over a several seconds.

Robotic-assisted gait training

Intervention Type DEVICE

Robotic-assisted gait training with an exoskeletal type robot which simulates normal walking on a treadmill for patients with gait impairments

Interventions

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tDCS

tDCS will be applied on the primary motor cortex of the lower limb in the impared hemisphere before robotic-assisted gait training. Anodal tDCS will be applied with an intensity of 2mA for 20 min. Sham tDCS will be applied with an intensity of 2mA just for 1 min, after which the current will be slowly tapered down to 0 over a several seconds.

Intervention Type DEVICE

Robotic-assisted gait training

Robotic-assisted gait training with an exoskeletal type robot which simulates normal walking on a treadmill for patients with gait impairments

Intervention Type DEVICE

Other Intervention Names

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DC-Stimulator Plus (NeuroConn GmbH, Ilmenaus, Germany) Walkbot_S (P&S Mechanics Co. Ltd., Seoul, Korea)

Eligibility Criteria

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Inclusion Criteria

* Stroke patients who diagnosed by computed tomography or magnetic resonance imaging
* Hemiplegic patients due to unilateral lesion
* Patients in chronic stage after 6 months from stroke onset
* Patients with gait impairment (FAC \<= 4)
* Adult (Age \>= 18)

Exclusion Criteria

* Unstable vital sign
* History of seizure or cranial operation
* unable to walk before stroke
* bilateral hemispheric lesions
* metalic implant (cardiac pacemaker, artificial cochlear, etc.)
* severe cognitive deficit, MMSE \< 10
* severe aphasic patient who cannot communicate at all
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Byung-Mo Oh

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Byung-Mo Oh, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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Robot-tDCS-2013

Identifier Type: -

Identifier Source: org_study_id