Glycemic Impact of Myo-inositol in Pregnancy

NCT ID: NCT02149992

Last Updated: 2016-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-30

Study Completion Date

2016-08-31

Brief Summary

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Myo-inositol has been shown to decrease the rate of diabetes in pregnancy in European studies. It is not known exactly how this occurs or what it does to the sugar when the supplement is taken. This study purpose is to look at the patient's sugar levels while taking the supplement to see if the overall levels of sugar go down. We hypothesize that in addition to sugar levels, other hormones influencing diabetes will be altered.

Detailed Description

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Myo-inositol is important for glucose homeostasis and has been shown to improve insulin sensitivity. This is a prospective cohort pilot study to determine daily glycemic pharmacokinetics and metabolic influences of myo-inositol supplementation using continuous glucose monitoring system (CGMS) and pre- and post-supplement blood work in high risk pregnancies and women diagnosed with gestational diabetes mellitis (GDM). Risk factors include: obesity, previous pregnancy with GDM, family history of diabetes, glucose intolerance, and polycystic ovarian syndrome (PCOS). Women will have a CGMS device placed on day one and begin with 3 days of placebo plus folic acid (400mcg) to determine baseline glycemia and metabolic levels. For the final 4 days, women with take myo-inositol supplementation (4g) plus folic acid (400mcg). The CGMS device will be removed on day 7 when final blood work will be obtained. Self-capillary glucose testing 4 times per day is recorded to calibrate CGMS glucose values. These observations will help determine the effects of myo-inositol on overall mean glucose and other metabolic factors in high risk and GDM patients, identify pharmacokinetic discipline in pregnancy, and develop the groundwork for future prospective clinical trials for the prevention and/or augmentation in treatment GDM.

Conditions

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Gestational Diabetes Mellitus as Antepartum Condition

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Myo-inositol, folic acid

1. myo-inositol, oral, 2g, two times per day for 5 total days
2. folic acid, oral 200 micrograms, two times per day for 7 days
3. Continuous Glucose Monitoring Surveillance device for 7 days during study period
4. Capillary glucose monitoring 4 times per day

Group Type EXPERIMENTAL

myo-inositol

Intervention Type DIETARY_SUPPLEMENT

myo-inositol, oral, 2g, twice a day for 5 days total

Continuous glucose monitoring surveillance

Intervention Type DEVICE

monitoring device will be placed by experienced research members to the patient on Day 1 and she will continue to wear until Day 7. This device monitors overall glycemia every 5 minutes and records the information, which can be downloaded after discontinued.

Glucose monitoring

Intervention Type DEVICE

patients will use the glucose meter, test strips, and lancets to determine her capillary glucose levels 4 times per day (fasting, and 1 hour post-prandial levels)

Interventions

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myo-inositol

myo-inositol, oral, 2g, twice a day for 5 days total

Intervention Type DIETARY_SUPPLEMENT

Continuous glucose monitoring surveillance

monitoring device will be placed by experienced research members to the patient on Day 1 and she will continue to wear until Day 7. This device monitors overall glycemia every 5 minutes and records the information, which can be downloaded after discontinued.

Intervention Type DEVICE

Glucose monitoring

patients will use the glucose meter, test strips, and lancets to determine her capillary glucose levels 4 times per day (fasting, and 1 hour post-prandial levels)

Intervention Type DEVICE

Other Intervention Names

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Inositol Medtronic CGMS OneTouch glucose meter test strips lancets

Eligibility Criteria

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Inclusion Criteria

* English-speaking
* singleton
* pregnant females between 20-28 weeks of gestation at time of enrollment PLUS (either of the following)
* High risk including women must have passed routine glucose screening and have greater than or equal to 1 of the following high risk criteria: first degree family member with diabetes mellitus, previous pregnancy with gestational diabetes, PCOS, or body mass index great than or equal to 30.
* Gestational diabetes diagnosed in current pregnancy based on IADPSG or NIH consensus diagnostic recommendation

Exclusion Criteria

* pre-pregnancy diagnosis of diabetes mellitus
* renal disease
* immunocompromised
* currently taking immunosuppressive medications
* age \<13 years old
* non-English speaking
* multifetal gestation.
Minimum Eligible Age

13 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Duke University

OTHER

Sponsor Role collaborator

Washington University School of Medicine

OTHER

Sponsor Role collaborator

Oregon Health and Science University

OTHER

Sponsor Role lead

Responsible Party

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Amy Valent

DO; Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Amy M Valent, DO

Role: PRINCIPAL_INVESTIGATOR

Test Organization

Locations

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Oregon Health and Science University

Portland, Oregon, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Amy M Valent, DO

Role: CONTACT

503-502-7220

Leonardo Pereira, MD

Role: CONTACT

503-494-2101

Facility Contacts

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Amy M Valent, DO

Role: primary

503-502-7220

Other Identifiers

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2014-1676

Identifier Type: -

Identifier Source: org_study_id

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