Helsinki Ultra-acute Stroke Biomarker Study

NCT ID: NCT02145663

Last Updated: 2016-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1046 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-05-31

Brief Summary

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The aim of this study is to establish diagnostic and predictive biomarkers for patients with suspected acute stroke, that are transported by EMS as candidates for thrombolytic treatment. The study focuses on the ultra acute phase, \<4.5 hours from symptom onset, including the prehospital setting. Analyses will include known biomarkers (e.g. GFAP, NR2 peptide) and a discovery phase for novel markers. Patient outcome will be evaluated at 3 month using the modified Rankin Scale (mRS).

Detailed Description

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Conditions

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Acute Stroke

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Acute stroke suspected by EMS personnel
* Transport to tertiary hospital as possible candidate for thrombolytic treatment of ischemic stroke
* Age ≥18
* Successful prehospital blood sampling by EMS personnel

Exclusion Criteria

* Unsuccessful prehospital blood sampling by EMS personnel
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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HUS area Prehospital Emergency Service

UNKNOWN

Sponsor Role collaborator

Helsinki University Central Hospital

OTHER

Sponsor Role lead

Responsible Party

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Perttu Lindsberg

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Perttu Lindsberg, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Helsinki University Central Hospital

Locations

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Helsinki University Central Hospital

Helsinki, Uusimaa, Finland

Site Status

Countries

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Finland

References

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Mattila OS, Puolakka T, Ritvonen J, Pihlasviita S, Harve H, Alanen A, Sibolt G, Curtze S, Strbian D, Pystynen M, Tatlisumak T, Kuisma M, Lindsberg PJ. Targets for improving dispatcher identification of acute stroke. Int J Stroke. 2019 Jun;14(4):409-416. doi: 10.1177/1747493019830315. Epub 2019 Feb 13.

Reference Type DERIVED
PMID: 30758276 (View on PubMed)

Other Identifiers

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MNEURT ISCHEMIC STROKE 813

Identifier Type: OTHER

Identifier Source: secondary_id

HUSBS2013

Identifier Type: -

Identifier Source: org_study_id

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