The Effect of Exercises on Physiological Changes and Clinical Symptoms in Allergic Rhinitis Patients
NCT ID: NCT02123914
Last Updated: 2015-08-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
27 participants
INTERVENTIONAL
2012-01-31
2014-08-31
Brief Summary
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2. Moderate exercise training combined with vitamin C supplementation decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
3. Moderate exercise training combined with vitamin C supplementation has more beneficial effects than moderate exercise training alone for decreasing cytokine response and rhinitis symptoms in patients with allergic rhinitis
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
SINGLE
Study Groups
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Aerobic exercise with Vit. C & Aerobic exercise
Aerobic exercise with Vit. C
walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week combined with taking vitamin C supplemented daily with an oral dose of 2,000 mg 2 times/day for 8 weeks.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
Aerobic exercise
walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week for 8 weeks.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
exercise without vit. c supplement & no exercise
Aerobic exercise with Vit. C
walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week combined with taking vitamin C supplemented daily with an oral dose of 2,000 mg 2 times/day for 8 weeks.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
No exercise
Sedentary control.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
Interventions
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Aerobic exercise with Vit. C
walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week combined with taking vitamin C supplemented daily with an oral dose of 2,000 mg 2 times/day for 8 weeks.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
Aerobic exercise
walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week for 8 weeks.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
No exercise
Sedentary control.
Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid,
Nasal peak flow measurement,
Nasal blood flow measurement,
Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.
Eligibility Criteria
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Exclusion Criteria
18 Years
45 Years
ALL
No
Sponsors
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Chulalongkorn University
OTHER
Responsible Party
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Assoc. Prof. Dr.Daroonwan Suksom
Faculty of Sports Science
Principal Investigators
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Daroonwan Suksom, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Faculty of Sports Science, Chulalongkorn University
Locations
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Faculty of Sports Science, Chulalongkorn University
Patumwan, Bangkok, Thailand
Countries
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References
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Klaewsongkram J, Ruxrungtham K, Wannakrairot P, Ruangvejvorachai P, Phanupak P. Eosinophil count in nasal mucosa is more suitable than the number of ICAM-1-positive nasal epithelial cells to evaluate the severity of house dust mite-sensitive allergic rhinitis: a clinical correlation study. Int Arch Allergy Immunol. 2003 Sep;132(1):68-75. doi: 10.1159/000073266.
Other Identifiers
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SPSC-2
Identifier Type: -
Identifier Source: org_study_id
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