Safety, Tolerability and Performance Profile of the Colospan Device CG-100 in Patients Undergoing Colorectal Surgery

NCT ID: NCT02109991

Last Updated: 2017-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2017-10-31

Brief Summary

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The purpose of this study is to evaluate the CG-100 device, a single use, temporary intraluminal bypass device,intended to reduce contact of fecal content with an anastomotic site, following colorectal surgery (open or laparoscopic).

Detailed Description

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Conditions

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Gastrointestinal Anastomosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CG-100 device

Group Type EXPERIMENTAL

CG-100 device

Intervention Type DEVICE

Colorectal surgery performed per standard of care with deployment of the CG-100 device in the anastomosis site

Interventions

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CG-100 device

Colorectal surgery performed per standard of care with deployment of the CG-100 device in the anastomosis site

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* The patient is scheduled to undergo an elective colorectal surgery (open or laparoscopic) which will require the creation of an anastomosis, maximally 20 cm proximal from the anal verge
* The patient is willing to comply with protocol-specified follow-up evaluations
* The patient signed Informed Consent

Exclusion Criteria

* Pregnant or nursing female subjects
* Patient surgical treatment is acute (not elective)
* Patient has infections at the time of intervention
* Major surgical or interventional procedures within 30 days prior to this study or planned surgical or interventional procedures within 30 days of entry into this study
* Patients with ASA (American Society of Anesthesiologists) classification \> 3
* diagnosis of bowel obstruction, bowel strangulation, peritonitis, bowel perforation, local or systemic infection, ischemic bowel, carcinomatosis or extensively spread inflammatory bowel disease
* Patient is participating in another clinical trial within 30 days of screening
* Patient has been taking regular steroid medication in the last 6 months
* Contraindications to general anesthesia
* Patient has preexisting sphincter problems or evidence of extensive local disease in the pelvis
* Internal diameter lumen of the colon is smaller than 25 mm or larger than 34 mm
* Blood loss (\> 500 cc)
* Leak test failure during surgery
* Any condition or surgical incidence where the device deployment can jeopardize the patient's safety or interferes with study outcome per the discretion of the investigator
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Colospan Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ziekenhuis Oost-Limburg

Genk, , Belgium

Site Status

UZ Gent

Ghent, , Belgium

Site Status

KBC Zagreb

Zagreb, , Croatia

Site Status

Jahn Ferenc Hospital

Budapest, , Hungary

Site Status

National Institute of Oncology

Budapest, , Hungary

Site Status

Soroka Medical Center

Beersheba, , Israel

Site Status

Rabin Medical Center

Petah Tikva, , Israel

Site Status

Assuta Medical Center

Tel Aviv, , Israel

Site Status

Countries

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Belgium Croatia Hungary Israel

Other Identifiers

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CLD-001

Identifier Type: -

Identifier Source: org_study_id