Compression Anastomosis For Low Anterior Resection in Previously Radiated Patients Using the CAR™ 27

NCT ID: NCT01056796

Last Updated: 2011-06-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2012-05-31

Brief Summary

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The purpose of this study is:

Evaluation of the safety and effectiveness of the Compression Anastomosis Ring (CAR™ 27) device for creation of circular, colorectal anastomoses in previously radiated patients.

Detailed Description

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Conditions

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Colorectal Cancer

Keywords

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compression anastomosis Colorectal cancer Low anterior resection Radiated to the pelvic area Radiotherapy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CAR™ 27

Any patient with a diagnosis of colorectal cancer that has been previously radiated to the pelvic area (6-8 weeks prior to surgery) and that is electively scheduled for an open or laparoscopic total mesorectal excision (TME) and low anterior resection surgery (\< 10cm from the anal verge) which requires the creation of an anastomosis, will be offered participation in this study.

Group Type EXPERIMENTAL

CAR™ 27

Intervention Type DEVICE

Creation of a low colorectal (side or pouch low rectal) compression anastomosis in previously radiated patients

Interventions

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CAR™ 27

Creation of a low colorectal (side or pouch low rectal) compression anastomosis in previously radiated patients

Intervention Type DEVICE

Other Intervention Names

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Compression Anastomosis Ring

Eligibility Criteria

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Inclusion Criteria

* Patient is ≥ 18 years old.
* Patient is scheduled for a non-emergency TME and low anterior resection (\< 10cm from the anal verge).
* Patient has been radiated to the pelvic area 6-8 weeks prior to the study.
* Subject signs and dates a written informed consent form (ICF) and indicates an understanding of the study procedures.

Exclusion Criteria

* Patient has known allergy to nickel.
* Patient undergoing an emergency procedure or has a diagnosis of bowel obstruction, bowel strangulation, peritonitis, bowel perforation, local or systemic infection, ischemic bowel, carcinomatosis or inflammatory bowel disease.
* Patients are participating in another clinical trial which may affect this study's outcomes.
* Patient has been taking regular steroid medication.
* Patient has contraindications to general anesthesia.
* Patient has preexisting sphincter problems or evidence of extensive local disease in the pelvis.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Gasthuisberg

OTHER

Sponsor Role collaborator

Niti Medical Technologies Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Gasthuisberg University Hospital, Leuven, Belgium

Principal Investigators

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Andre D'Hoore, Professor

Role: PRINCIPAL_INVESTIGATOR

Gasthuisberg University Hospital

Locations

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University Hospital, Gasthuisberg

Leuven, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Andre D'Hoore, Professor

Role: CONTACT

Phone: +32 (16) 344265

Email: [email protected]

Yael Nir, MD

Role: CONTACT

Phone: +972 (9) 8603000

Email: [email protected]

Facility Contacts

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Andre D'Hoore, Professor

Role: primary

Guido Van Ermen, Mr.

Role: backup

Other Identifiers

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Version: January 6, 2010

Identifier Type: -

Identifier Source: org_study_id