Swiss Atrial Fibrillation Cohort Study

NCT ID: NCT02105844

Last Updated: 2025-07-09

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 2415 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-03-31
• Study Completion Date: 2030-03-31

Brief Summary

Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged >65 years will be included and followed on a yearly basis.

Yearly clinical examinations include a detailed questionnaire on personal characteristics, a resting electrocardiogram, neurocognitive function tests and questionnaires on disability and quality of life. Blood sampling and brain magnetic resonance imaging are scheduled at baseline and after 2 years of follow-up.

The main study aims of this long term prospective study are to increase our knowledge on structural brain damage and its changes over time in patients with atrial fibrillation, to gain additional insights on the incidence and underlying mechanisms of cognitive decline in patients with atrial fibrillation and to evaluate the interrelationships of structural and functional brain damage in this population.

Conditions

Atrial Fibrillation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Atrial Fibrillation

Cohort Study on patients with atrial fibrillation in Switzerland

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• atrial fibrillation documented within the last 24 months
• age >=45 years

Exclusion Criteria

• acute illness
• inability to provide informed consent
• Only short episodes of reversible forms of atrial fibrillation

• Minimum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Swiss National Science Foundation

OTHER

Sponsor Role: collaborator

Medical Image Analysis Center (MIAC) Basel

UNKNOWN

Sponsor Role: collaborator

Schiller AG Baar

UNKNOWN

Sponsor Role: collaborator

Clinical Trial Unit, University Hospital Basel, Switzerland

OTHER

Sponsor Role: collaborator

Cardiovascular Research Institute (CRIB) Basel

UNKNOWN

Sponsor Role: collaborator

Cardiocentro Ticino

OTHER

Sponsor Role: collaborator

University Hospital, Basel, Switzerland

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Stefan Osswald, MD, Prof.

Role: STUDY_DIRECTOR

University Hospital, Basel, Switzerland

Michael Kuehne, MD, PD, exec. MBA

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Basel, Switzerland

David Conen, MD MPH

Role: PRINCIPAL_INVESTIGATOR

McMaster University, Population Health Research Institute, Hamilton, Canada

Locations

University Hospital

Basel, Canton of Basel-City, Switzerland

Countries

Switzerland

References

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Other Identifiers

SWISS-AF

Identifier Type: -

Identifier Source: org_study_id