Observational Study of Sinus Rhythm Mapping in Pulmonary Vein Isolation Naive Patients With Atrial Fibrillation

NCT ID: NCT06098664

Last Updated: 2023-10-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-26

Study Completion Date

2023-12-01

Brief Summary

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Atrial fibrillation (AF) initially starts in a paroxysmal form, which is mainly based on the presence of triggers. Progression of AF is accompanied by structural and electrical remodelling which can typically be described as a progressive change in electrophysiological properties of the myocardium caused by cardiovascular comorbidities and AF itself. This results in complex electrical conduction disorders, which is defined as electropathology. The aim of our study is to evaluate whether an artificial intelligence (AI)-enabled ECG algorithm (on an ECG in Sinus Rhythm) can predict electropathology in patients with AF who undergo a first PVI.

Detailed Description

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Conditions

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Atrial Fibrillation

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Low score group (DNN-score = 0 - 10%)

The inclusions will be stratified to the deep neural network (DNN) score. The study will enrol 20 patients in each group.

AI-enabled ECG score for Atrial Fibrillation (DNN score)

Intervention Type DIAGNOSTIC_TEST

A 12-lead ECG, performed within 24 hours before the Pulmonary Vein Isolation (PVI) procedure, will be used to calculate the DNN score.

(DNN score details: https://doi.org/10.1016/j.jacep.2023.04.008)

Atrial voltage map in sinus rhythm

Intervention Type DIAGNOSTIC_TEST

An atrial voltage map will be constructed prior to the PVI procedure.

Medium score group (DNN-score = 10 - 50%)

The inclusions will be stratified to the deep neural network (DNN) score. The study will enrol 20 patients in each group.

AI-enabled ECG score for Atrial Fibrillation (DNN score)

Intervention Type DIAGNOSTIC_TEST

A 12-lead ECG, performed within 24 hours before the Pulmonary Vein Isolation (PVI) procedure, will be used to calculate the DNN score.

(DNN score details: https://doi.org/10.1016/j.jacep.2023.04.008)

Atrial voltage map in sinus rhythm

Intervention Type DIAGNOSTIC_TEST

An atrial voltage map will be constructed prior to the PVI procedure.

High score group (DNN-score = 50 - 100%)

The inclusions will be stratified to the deep neural network (DNN) score. The study will enrol 20 patients in each group.

AI-enabled ECG score for Atrial Fibrillation (DNN score)

Intervention Type DIAGNOSTIC_TEST

A 12-lead ECG, performed within 24 hours before the Pulmonary Vein Isolation (PVI) procedure, will be used to calculate the DNN score.

(DNN score details: https://doi.org/10.1016/j.jacep.2023.04.008)

Atrial voltage map in sinus rhythm

Intervention Type DIAGNOSTIC_TEST

An atrial voltage map will be constructed prior to the PVI procedure.

Interventions

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AI-enabled ECG score for Atrial Fibrillation (DNN score)

A 12-lead ECG, performed within 24 hours before the Pulmonary Vein Isolation (PVI) procedure, will be used to calculate the DNN score.

(DNN score details: https://doi.org/10.1016/j.jacep.2023.04.008)

Intervention Type DIAGNOSTIC_TEST

Atrial voltage map in sinus rhythm

An atrial voltage map will be constructed prior to the PVI procedure.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Provide signed and dated informed consent.
* First PVI-procedure
* Age is 18 years or higher.
* 12-lead ECG available in SR during the last 14 days.

Exclusion Criteria

* Mitral insufficiency of grade 3 or 4.
* Participating in another study that may interfere with participation in this study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ziekenhuis Oost-Limburg

OTHER

Sponsor Role lead

Responsible Party

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Laurent Pison

Clinical professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ziekenhuis Oost-Limburg

Genk, Limburg, Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Henri M.P.B.C. Gruwez, MD

Role: CONTACT

+3289212051

Facility Contacts

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Henri Gruwez, MD

Role: primary

+3289212051

CTU Clinical Trial Unit

Role: backup

+3289212021

Other Identifiers

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Z-2023039

Identifier Type: -

Identifier Source: org_study_id

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