Long Term Stability, Survival and Tolerability of a (Novel) Baha® Implant System

NCT ID: NCT02092610

Last Updated: 2016-02-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

77 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2015-03-31

Brief Summary

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An international multicentre, open, comparative, parallel group, prospective clinical investigation with a single 5 year follow up visit.

Detailed Description

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Two implant products, the standard implant and abutment and the novel implant and abutment, both developed by Cochlear Bone Anchored Solutions AB were tested in the CAG5173 clinical investigation that was completed in December 2012. The primary objective was to show superiority of the novel implant compared to standard implant in terms of implant stability quotient (ISQ) as as measured by resonance frequency analysis1. Results after 6 and 36 months after implantation showed that the new design, the novel implant and abutment, provided statistically significantly higher stability at the time of insertion and over time compared to the standard Baha implant2,3,4. In the investigation, sound processor fitting was performed from 6 weeks post-implantation. No reduction in implant stability following sound processor fitting was recorded, suggesting that it is safe to load the implant 6 weeks after implantation. The investigation also showed improved soft tissue outcomes, in terms of lower Holgers index5 scores for the novel implant and abutment compared to the standard implant and abutment.

After initiation of the 3-year CAG5173 investigation, Cochlear Bone Anchored Solutions AB launched the Cochlear Baha BIA300 Implant and Abutment, which in all critical aspects are identical to the novel implant used in the investigation.

The 36-month visit was the last visit of the investigation. Hence, no further visits were planned or scheduled for the subjects participating in that investigation.participating subjects. It is of clinical and scientific interest to evaluate the clinical performance and safety data of the implants in these subjects after an additional two-year period, in order to gain additional understanding of how implant stability and soft tissue status evolves over time with the two implant and abutment designs, and in order to evaluate long-term implant survival. No randomised controlled investigation of Baha implants with a 5-year follow-up has been conducted to date.

The rationale behind this clinical investigation is to collect long term stability, survival and tolerability data of a novel Baha implant system 5 years after implantation in a population that previously have been followed in a completed controlled investigation during a 3 year period. The collected data will enable comparison with the data gathered in the previous completed CAG5173 clinical investigation.

Conditions

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Conductive Hearing Loss

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Standard Implant BI300

The product was the standard titanium implant and abutment in the Baha system developed by Cochlear Bone Anchored Solutions AB. The implant is 3.75 mm wide and 4.0 mm long

Group Type ACTIVE_COMPARATOR

Standard Implant BI300

Intervention Type DEVICE

The Standard Implant BI300 was the standard titanium implant and abutment in the Baha system developed by Cochlear Bone Anchored Solutions AB. The implant is 3.75 mm wide and 4.0 mm long

Novel Implant BI300

The product was the novel titanium implant and abutment for the Baha system developed by Cochlear Bone Anchored Solutions AB. The novel implant is 4.5 mm wide and 4.0 mm long.

Group Type EXPERIMENTAL

Novel Implant BI300

Intervention Type DEVICE

The Novel Implant BI300 was the new titanium implant and abutment for the Baha system developed by Cochlear Bone Anchored Solutions AB. The novel implant is 4.5 mm wide and 4.0 mm long.

Interventions

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Novel Implant BI300

The Novel Implant BI300 was the new titanium implant and abutment for the Baha system developed by Cochlear Bone Anchored Solutions AB. The novel implant is 4.5 mm wide and 4.0 mm long.

Intervention Type DEVICE

Standard Implant BI300

The Standard Implant BI300 was the standard titanium implant and abutment in the Baha system developed by Cochlear Bone Anchored Solutions AB. The implant is 3.75 mm wide and 4.0 mm long

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Participated in the CAG5173 investigation
* Signed informed consent

Exclusion Criteria

* Unable to follow investigational procedure
* Any factor, at the discretion of the investigator, that is considered to contraindicate participation
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cochlear Bone Anchored Solutions

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Johan Blechert, M.Sc

Role: STUDY_DIRECTOR

Cochlear Bone Anchored Solutions AB

Locations

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Radboud University Medical Center

Nijmegen, , Netherlands

Site Status

Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status

Manchester Royal Infirmary

Manchester, , United Kingdom

Site Status

Salford Royal hospital

Salford, Manchester, , United Kingdom

Site Status

Countries

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Netherlands Sweden United Kingdom

Other Identifiers

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CBAS5562

Identifier Type: -

Identifier Source: org_study_id

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